Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets
NOL carryforwards	$ 225,993	$ 229,476
R&D credit carryforwards	83,074	74,702
Stock-based compensation	51,661	51,170
Charitable contributions	42,677	41,355
Capitalized R&D	38,507	0
Intangibles	24,030	6,741
Lease liabilities	14,730	15,550
Other	13,770	11,700
Total deferred tax assets	494,442	430,694
Valuation allowance	(481,210)	(416,630)
Deferred tax liabilities
Right-of-use assets	(13,203)	(14,063)
Propery and equipment	(29)	(1)
Total deferred tax liabilities	(13,232)	(14,064)
Total net deferred tax assets	$ 0	$ 0

Deferred tax assets lease obligations.

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Deferred tax liabilities right of use assets.

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Amount, after deferred tax asset, of deferred tax liability attributable to taxable differences with jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible charitable contribution carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from intangible assets including goodwill.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from in-process research and development costs expensed in connection with a business combination.

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from share-based compensation.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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Amount of deferred tax liability attributable to taxable temporary differences from property, plant, and equipment.

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