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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (44,823)	$ (35,179)	$ (59,004)
Stock-based compensation and other permanent differences	9,050	6,696	991
Write-off of IP R&D	2,449	1,277	9,565
R&D credits	(9,974)	(11,727)	(17,909)
Change in valuation allowance	11,227	36,099	5,925
State taxes	(2,232)	(2,617)	(5,038)
Contingencies	6,993	3,879	2,665
Foreign rate differential	(1,971)	2,857	4,208
Limitation on executive compensation	3,918	1,808	3,705
Deferred rate adjustment	922	(2,424)	2,130
Switzerland tax reform	0	(923)	53,045
Epiration of attributes	16,142	0	0
GILTI	10,804
Other	(26)	605	328
Income tax expense	$ 2,531	$ 351	$ 611

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