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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Jan. 31, 2022
Aug. 31, 2018
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2018
Dec. 31, 2022
Dec. 31, 2021
Other Commitments [Line Items]              
Gain (loss) on strategic investment     $ 4,845 $ 339      
Research and development     69,144 128,855      
Restricted cash     5,770 $ 5,770   $ 5,770 $ 5,770
Letter of Credit | Corporate Credit Card Program              
Other Commitments [Line Items]              
Restricted cash     2,000        
Letter of Credit | Fleet Program              
Other Commitments [Line Items]              
Restricted cash     400        
Stoke Therapeutics, Inc. [Member] | Research and Development [Member]              
Other Commitments [Line Items]              
Collaborative Arrangements Upfront Consideration And Transaction Payment $ 60,000            
Mile stone payments payable 907,500            
Upfront consideration and transaction costs $ 60,000            
Collaboration Agreement, Cost Splits Description For the SYNGAP1 program, the two companies will jointly share global research, development and commercialization responsibilities and share 50/50 in all worldwide costs and future profits            
License Agreements | North America              
Other Commitments [Line Items]              
Mile stone payments payable     40,000        
Upfront payment     40,000        
License Agreements | Neuren | North America              
Other Commitments [Line Items]              
Upfront license fee   $ 10,000          
Milestone payment as intangible asset     40,000        
PRV liability     29,600        
License Agreements | Neuren | Research and Development [Member] | North America              
Other Commitments [Line Items]              
Upfront payment         $ 10,000    
Maximum              
Other Commitments [Line Items]              
Mile stone payments payable     $ 1,600,000        
Maximum | License Agreements | Neuren | North America              
Other Commitments [Line Items]              
Mile stone payments payable   $ 455,000