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Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Revenues    
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 118,462 $ 115,468
Operating expenses    
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 1,667 $ 2,950
Research and development 69,144 128,855
Selling, general and administrative 101,235 96,679
Total operating expenses 172,046 228,484
Loss from operations (53,584) (113,016)
Interest income, net 3,800 105
Other income 4,845 340
Loss before income taxes (44,939) (112,571)
Income tax (benefit) expense (1,918) 485
Net loss $ (43,021) $ (113,056)
Net loss per common share, basic $ (0.27) $ (0.70)
Net loss per common share, diluted $ (0.27) $ (0.70)
Weighted average common shares outstanding, basic 162,263 161,231
Weighted average common shares outstanding, diluted 162,263 161,231