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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities    
Net loss $ (43,021) $ (113,056)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 14,705 14,963
Amortization of premiums and accretion of discounts on investment securities (2,267) 447
Gain on strategic investment (4,845) (339)
Loss on sale of investment securities 505 0
Depreciation 426 516
Changes in operating assets and liabilities:    
Accounts receivable, net (3,720) 1,653
Interest and other receivables (3,450) 209
Inventory 481 833
Prepaid expenses (2,234) (1,863)
Operating lease right-of-use assets 1,726 1,522
Accounts payable 4,676 3,892
Accrued liabilities 24,510 19,672
Operating lease liabilities (1,656) (2,117)
Long-term liabilities (3,769) (2,661)
Net cash used in operating activities (17,933) (76,329)
Cash flows from investing activities    
Purchases of investment securities (66,892) 0
Sale and maturity of investment securities 259,410 131,345
Net cash provided by investing activities 192,518 131,345
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 1,466 2,467
Net cash provided by financing activities 1,466 2,467
Effect of exchange rate changes on cash (2) 2
Net increase (decrease) in cash, cash equivalents and restricted cash 176,049 57,485
Cash, cash equivalents and restricted cash    
Beginning of period 120,616 153,205
End of period 296,665 210,690
Supplemental disclosure of noncash information:    
Accrued milestone and contingent payments in connection with asset acquisition $ 69,583 $ 0