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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Jan. 31, 2022 | Aug. 31, 2018 | Jun. 30, 2023 | Mar. 31, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2018 | Dec. 31, 2022 | Dec. 31, 2021
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Loss (gain) on strategic investment |  |  |  |  |  | $ 3,601 | $ (158) |  |  |
Research and development |  |  | $ 58,771 |  | $ 75,646 | 127,915 | 204,501 |  |  |
Restricted cash |  |  | 8,120 |  | $ 5,770 | 8,120 | $ 5,770 |  | $ 5,770 | $ 5,770
Letter of Credit | Corporate Credit Card Program |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  | 2,000 |  |  | 2,000 |  |  |  |
Letter of Credit | Fleet Program |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Restricted cash |  |  | 400 |  |  | 400 |  |  |  |
Stoke Therapeutics, Inc. [Member] | Research and Development [Member] |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements Upfront Consideration And Transaction Payment | $ 60,000 |  |  |  |  |  |  |  |  |
Mile stone payments payable | 907,500 |  |  |  |  |  |  |  |  |
Upfront consideration and transaction costs | $ 60,000 |  |  |  |  |  |  |  |  |
Collaboration Agreement, Cost Splits Description | For the SYNGAP1 program, the two companies will jointly share global research, development and commercialization responsibilities and share 50/50 in all worldwide costs and future profits |  |  |  |  |  |  |  |  |
License Agreements | North America |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  |  |  | $ 40,000 |  |  |  |  |  |
License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront license fee |  | $ 10,000 |  |  |  |  |  |  |  |
Milestone payment as intangible asset |  |  |  | 40,000 |  |  |  |  |  |
PRV liability |  |  |  | $ 29,600 |  |  |  |  |  |
License Agreements | Neuren | Research and Development [Member] | North America |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  | $ 10,000 |  |
Maximum |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  |  | $ 1,600,000 |  |  | $ 1,600,000 |  |  |  |
Maximum | License Agreements | Neuren | North America |  |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |
Mile stone payments payable |  | $ 455,000 |  |  |  |  |  |  |  |

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