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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Income Tax Disclosure [Abstract] |  |  |
Amounts computed at statutory federal rate | $ (10,718) | $ (44,823) | $ (35,179)
Stock-based compensation and other permanent differences | 8,458 | 7,596 | 6,083
Branded pharmaceutical drug fee | 1,848 | 1,454 | 613
Write-off of IP R&D | 0 | 2,449 | 1,277
R&D credits | (5,827) | (9,974) | (11,727)
Change in valuation allowance | 1,100 | 11,227 | 36,099
State taxes | (977) | (2,232) | (2,617)
Contingencies | (2,071) | 6,993 | 3,879
Foreign rate differential | (5,076) | (1,971) | 2,857
Deferred adjustments for limits on executive compensation | 2,112 | 3,918 | 1,808
Deferred rate adjustment | (192) | 922 | (2,424)
Switzerland tax reform | (246) | 0 | (923)
Epiration of attributes | 17,225 | 16,142 | 726
GILTI | 7,665 | 10,804 | 0
Other | (3,051) | 26 | (121)
Total income tax provision | $ 10,250 | $ 2,531 | $ 351

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