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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities |  |  |
Net loss | $ (61,286) | $ (215,975) | $ (167,870)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 66,421 | 68,201 | 63,615
Amortization of premiums and accretion of discounts on investment securities | (7,533) | (2,736) | 2,404
Amortization of intangible assets | 4,093 | 0 | 1,108
Gain on strategic investment | (5,109) | (3,542) | (2,329)
Depreciation | 1,459 | 2,026 | 2,236
Loss on sale of investment securities | 524 | 0 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | (36,072) | 2,171 | (16,119)
Interest and other receivables | (3,198) | 93 | 1,057
Inventory | (28,808) | 2,415 | (4,210)
Prepaid expenses and other current assets | (17,693) | 2,494 | 1,802
Operating lease right-of-use assets | 5,769 | 6,566 | 6,287
Other assets | (33) | (48) | 10
Accounts payable | 4,797 | 5,870 | (1,617)
Accrued liabilities | 93,170 | 24,306 | (8,455)
Operating lease liabilities | (5,872) | (7,916) | (5,433)
Long-term liabilities | 6,073 | 2,040 | 1,854
Net cash provided by (used in) operating activities | 16,702 | (114,035) | (125,660)
Cash flows from investing activities |  |  |
Purchases of investment securities | (369,985) | (363,174) | (492,797)
Sale and maturity of investment securities | 429,780 | 436,415 | 422,817
Proceeds from sales of strategic investment | 12,253 | 0 | 0
Net purchases of property and equipment | (50) | 0 | (1,122)
Intangible assets | (40,000) | 0 | 0
Net cash provided by (used in) investing activities | 31,998 | 73,241 | (71,102)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 25,129 | 8,199 | 18,162
Net cash provided by financing activities | 25,129 | 8,199 | 18,162
Effect of exchange rate changes on cash | (18) | 6 | 7
Net increase (decrease) in cash, cash equivalents and restricted cash | 73,811 | (32,589) | (178,593)
Cash, cash equivalents and restricted cash |  |  |
Beginning of period | 120,616 | 153,205 | 331,798
End of period | 194,427 | 120,616 | 153,205
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 5,850 | 2,190 | 1,038
Supplemental disclosure of noncash information: |  |  |
Accrued milestone and contingent payments in connection with asset acquisition | $ 29,583 | $ 0 | $ 0

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