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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Revenues      
Type of Revenue [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Total revenues $ 726,437 $ 517,235 $ 484,145
Operating expenses      
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Cost of product sales $ 41,638 $ 10,166 $ 19,141
Research and development 351,619 361,575 239,415
Selling, general and administrative 406,559 369,090 396,028
Total operating expenses 799,816 740,831 654,584
Loss from operations (73,379) (223,596) (170,439)
Interest income, net 17,234 6,610 591
Other income 5,109 3,542 2,329
Loss before income taxes (51,036) (213,444) (167,519)
Income tax expense 10,250 2,531 351
Net loss $ (61,286) $ (215,975) $ (167,870)
Net loss per common share, basic $ (0.37) [1] $ (1.34) [1] $ (1.05)
Net loss per common share, diluted $ (0.37) [1] $ (1.34) [1] $ (1.05)
Weighted average common shares outstanding, basic 163,819 161,683 160,493
Weighted average common shares outstanding, diluted 163,819 161,683 160,493
[1] Basic and diluted net income (loss) per common share are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net income (loss) per common share amounts may not equal the annual amounts reported.