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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($)
$ in Thousands
Dec. 31, 2023
Dec. 31, 2022
Deferred tax assets    
NOL carryforwards $ 149,049 $ 225,993
R&D credit carryforwards 70,906 83,074
Capitalized R&D 90,164 38,507
Stock-based compensation 51,028 51,661
Charitable contributions 40,956 42,677
Lease liabilities 13,671 14,730
Intangibles 43,220 24,030
Property and equipment 51 0
Accrued rebates 19,401 5,748
Other 16,036 8,022
Total deferred tax assets 494,482 494,442
Valuation allowance (482,089) (481,210)
Deferred tax liabilities    
Propery and equipment 0 (29)
Right-of-use assets (12,393) (13,203)
Total deferred tax liabilities (12,393) (13,232)
Total net deferred tax assets $ 0 $ 0