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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (10,718)	$ (44,823)	$ (35,179)
Stock-based compensation and other permanent differences	8,458	7,596	6,083
Branded pharmaceutical drug fee	1,848	1,454	613
Write-off of IP R&D	0	2,449	1,277
R&D credits	(5,827)	(9,974)	(11,727)
Change in valuation allowance	1,100	11,227	36,099
State taxes	(977)	(2,232)	(2,617)
Contingencies	(2,071)	6,993	3,879
Foreign rate differential	(5,076)	(1,971)	2,857
Deferred adjustments for limits on executive compensation	2,112	3,918	1,808
Deferred rate adjustment	(192)	922	(2,424)
Switzerland tax reform	(246)	0	(923)
Epiration of attributes	17,225	16,142	726
GILTI	7,665	10,804	0
Other	(3,051)	26	(121)
Total income tax provision	$ 10,250	$ 2,531	$ 351

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