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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Jul. 31, 2023
Jan. 31, 2022
Aug. 31, 2018
Mar. 31, 2024
Mar. 31, 2023
Sep. 30, 2018
Sep. 30, 2023
Dec. 31, 2023
Dec. 31, 2022
Other Commitments [Line Items]                  
Contractual obligation next 12 months       $ 50,000          
Loss (gain) on strategic investment       0 $ 4,845        
Research and development       59,679 69,144        
Restricted cash       5,770 5,770     $ 5,770 $ 5,770
Letter of Credit | Corporate Credit Card Program                  
Other Commitments [Line Items]                  
Restricted cash       2,000          
Letter of Credit | Fleet Program                  
Other Commitments [Line Items]                  
Restricted cash       400          
Stoke Therapeutics, Inc. [Member] | Research and Development [Member]                  
Other Commitments [Line Items]                  
Collaborative Arrangements Upfront Consideration And Transaction Payment   $ 60,000              
Mile stone payments payable   907,500              
Upfront consideration and transaction costs   $ 60,000              
Collaboration agreement description   For the SYNGAP1 program, the two companies will jointly share global research, development and commercialization responsibilities and share 50/50 in all worldwide costs and future profits              
License Agreements | North America                  
Other Commitments [Line Items]                  
Mile stone payments payable         40,000        
License Agreements | Neuren | North America                  
Other Commitments [Line Items]                  
Upfront payment $ 100,000                
Mile stone payments payable       50,000          
Upfront license fee     $ 10,000            
Net sales       250,000          
Milestone payment as intangible asset         40,000        
PRV liability         $ 29,600        
License Agreements | Neuren | Research and Development [Member] | North America                  
Other Commitments [Line Items]                  
Upfront payment           $ 10,000 $ 100,000    
License Agreements | Neuren | Development Commercialization and Sales Milestones                  
Other Commitments [Line Items]                  
Upfront payment 831,300                
Maximum                  
Other Commitments [Line Items]                  
Mile stone payments payable       $ 3,400,000          
Maximum | License Agreements | Neuren | North America                  
Other Commitments [Line Items]                  
Mile stone payments payable $ 426,300   $ 455,000