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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Tax Disclosure [Abstract] |  |  |
Amounts computed at statutory federal rate | $ 54,196 | $ (10,718) | $ (44,823)
Stock-based compensation and other permanent differences | 9,986 | 7,865 | 7,459
Branded pharmaceutical drug fee | 2,122 | 1,848 | 1,454
Write-off of IP R&D | 1,260 | 0 | 2,449
Other permanent differences | 1,008 | 593 | 137
R&D credits | (18,406) | (5,827) | (9,974)
Change in valuation allowance | (27,013) | 1,100 | 11,227
State taxes | 3,050 | (977) | (2,232)
Contingencies | 5,960 | (2,071) | 6,993
Foreign rate differential | (13,715) | (5,076) | (1,971)
Deferred adjustments for limits on executive compensation | 2,375 | 2,112 | 3,918
Deferred rate adjustment | (528) | (438) | 922
Expiration of attributes | 3,264 | 17,225 | 16,142
GILTI | 8,215 | 7,665 | 10,804
Other | (150) | (3,051) | 26
Income tax expense | $ 31,624 | $ 10,250 | $ 2,531

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