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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Income Tax Disclosure [Abstract]

Summary of Domestic and Foreign Pre-tax Loss

Domestic and foreign pre-tax income (loss) is as follows (in thousands):

		Years Ended December 31,
		2024				2023				2022
Domestic		$	95,845			$	(100,215	)		$	(233,216	)
Foreign			162,230				49,179				19,772
		$	258,075			$	(51,036	)		$	(213,444	)

Schedule of income tax provision consists

The income tax provision consists of the following (in thousands):

		Years Ended December 31,
		2024				2023				2022
Current provision:
Federal		$	19,542			$	5,440			$	—
State			12,064				4,805				2,531
Foreign			18				5				—
Total current provision			31,624				10,250				2,531
Total income tax provision		$	31,624			$	10,250			$	2,531

Components of Deferred Tax Assets

The components of the deferred tax assets are as follows (in thousands):

		December 31,
		2024				2023
Deferred tax assets
NOL carryforwards		$	117,052			$	149,049
R&D credit carryforwards			27,543				70,906
Capitalized R&D			110,848				90,164
Stock-based compensation			51,438				51,028
Charitable contributions			40,008				40,956
Lease liabilities			12,753				13,671
Intangibles			50,431				43,220
Accrued rebates			35,186				19,401
Other			21,130				16,087
Total deferred tax assets			466,389				494,482
Valuation allowance			(454,966	)			(482,089	)
Deferred tax liabilities
Right-of-use assets			(11,423	)			(12,393	)
Total deferred tax liabilities			(11,423	)			(12,393	)
Total net deferred tax assets		$	—			$	—

Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss

A reconciliation of income taxes to the amount computed by applying the statutory federal income tax rate to the pretax income (loss) is summarized as follows (in thousands):

		Years Ended December 31,
		2024				2023				2022
Amounts computed at statutory federal rate		$	54,196			$	(10,718	)		$	(44,823	)
Stock-based compensation and other permanent differences			9,986				7,865				7,459
Branded pharmaceutical drug fee			2,122				1,848				1,454
Write-off of IP R&D			1,260				—				2,449
Other permanent differences			1,008				593				137
R&D credits			(18,406	)			(5,827	)			(9,974	)
Change in valuation allowance			(27,013	)			1,100				11,227
State taxes			3,050				(977	)			(2,232	)
Contingencies			5,960				(2,071	)			6,993
Foreign rate differential			(13,715	)			(5,076	)			(1,971	)
Deferred adjustments for limits on executive compensation			2,375				2,112				3,918
Deferred rate adjustment			(528	)			(438	)			922
Expiration of attributes			3,264				17,225				16,142
GILTI			8,215				7,665				10,804
Other			(150	)			(3,051	)			26
Income tax expense		$	31,624			$	10,250			$	2,531

Unrecognized Tax Benefits

The following table provides a reconciliation of changes in unrecognized tax benefits (in thousands):

		Years Ended December 31,
		2024				2023				2022
Balance at beginning of period		$	37,112			$	19,064			$	13,923
Additions related to current period tax positions			6,337				5,304				5,140
Additions related to prior period tax positions			—				12,956				38
Reductions related to prior period tax positions			(5,074	)			(212	)			(37	)
Balance at end of period		$	38,375			$	37,112			$	19,064

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