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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Tax Disclosure [Abstract]      
Amounts computed at statutory federal rate $ 54,196 $ (10,718) $ (44,823)
Stock-based compensation and other permanent differences 9,986 7,865 7,459
Branded pharmaceutical drug fee 2,122 1,848 1,454
Write-off of IP R&D 1,260 0 2,449
Other permanent differences 1,008 593 137
R&D credits (18,406) (5,827) (9,974)
Change in valuation allowance (27,013) 1,100 11,227
State taxes 3,050 (977) (2,232)
Contingencies 5,960 (2,071) 6,993
Foreign rate differential (13,715) (5,076) (1,971)
Deferred adjustments for limits on executive compensation 2,375 2,112 3,918
Deferred rate adjustment (528) (438) 922
Expiration of attributes 3,264 17,225 16,142
GILTI 8,215 7,665 10,804
Other (150) (3,051) 26
Income tax expense $ 31,624 $ 10,250 $ 2,531