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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2024
Jul. 31, 2023
Jan. 31, 2022
Aug. 31, 2018
May 31, 2018
Dec. 31, 2024
Sep. 30, 2023
Mar. 31, 2023
Sep. 30, 2018
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Other Commitments [Line Items]                        
Contractual obligation is payable within 60 days           $ 50,000       $ 50,000    
Gain (loss) on strategic investment                   0 $ 5,109 $ 3,542
Restricted cash           8,770       8,770 5,770 5,770
Corporate Credit Card Program | Letter of Credit                        
Other Commitments [Line Items]                        
Restricted cash           5,000       5,000    
Fleet Program | Letter of Credit                        
Other Commitments [Line Items]                        
Restricted cash           400       400    
Other expense                        
Other Commitments [Line Items]                        
Gain (loss) on strategic investment                   0 5,100 3,500
Stoke Therapeutics, Inc. | Research and development                        
Other Commitments [Line Items]                        
Milestone payments payable     $ 907,500                  
Upfront consideration and transaction costs     $ 60,000                  
Cost splits description     For the SYNGAP1 program, the two companies will jointly share global research, development and commercialization responsibilities and share 50/50 in all worldwide costs and future profits.                  
License Agreements                        
Other Commitments [Line Items]                        
Upfront payment                   34,500 102,500 $ 88,700
License Agreements | North America                        
Other Commitments [Line Items]                        
Milestone payments payable               $ 40,000        
License Agreements | Neuren | North America                        
Other Commitments [Line Items]                        
Upfront payment   $ 100,000                    
Milestone payment as intangible asset               40,000        
PRV liability               $ 29,600   19,200    
Net sales                   250,000    
Proceeds from Sale of Intangible Assets                   146,500    
Upfront license fee       $ 10,000                
License Agreements | Neuren | Research and development | North America                        
Other Commitments [Line Items]                        
Upfront payment             $ 100,000   $ 10,000      
License Agreements | NNZ-2591 | Development Commercialization and Sales Milestones                        
Other Commitments [Line Items]                        
Milestone payments payable   831,300                    
License Agreements | Saniona                        
Other Commitments [Line Items]                        
Upfront payment $ 28,000                      
License Agreements | Saniona | Research and development                        
Other Commitments [Line Items]                        
Upfront payment           28,000            
Exclusivity Deed | Neuren                        
Other Commitments [Line Items]                        
Aggregate carrying amount of strategic equity investment         $ 3,100              
Proceeds from sale of shares                     $ 12,300  
Shares subscribed         1,330,000              
Shares sold of Neuren                     1,330,000  
Exclusivity Deed | Neuren | Sales, general and administrative                        
Other Commitments [Line Items]                        
Payments for exclusive right         $ 900              
Maximum                        
Other Commitments [Line Items]                        
Milestone payments payable           $ 4,000,000       $ 4,000,000    
Maximum | License Agreements | Neuren | North America                        
Other Commitments [Line Items]                        
Milestone payments payable   $ 426,300   $ 455,000                
Maximum | License Agreements | Saniona                        
Other Commitments [Line Items]                        
Milestone payments payable 582,000                      
Maximum | License Agreements | Saniona | Sales                        
Other Commitments [Line Items]                        
Milestone payments payable 435,000                      
Maximum | License Agreements | Saniona | Development Commercialization and Sales Milestones                        
Other Commitments [Line Items]                        
Milestone payments payable $ 147,000