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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Nov. 30, 2024
Jul. 31, 2023
Jan. 31, 2022
Aug. 31, 2018
Mar. 31, 2025
Mar. 31, 2023
Sep. 30, 2018
Sep. 30, 2023
Dec. 31, 2024
Mar. 31, 2024
Dec. 31, 2023
Other Commitments [Line Items]                      
Restricted cash         $ 8,770       $ 8,770 $ 5,770 $ 5,770
Letter of Credit | Corporate Credit Card Program                      
Other Commitments [Line Items]                      
Restricted cash         5,000            
Letter of Credit | Fleet Program                      
Other Commitments [Line Items]                      
Restricted cash         400            
Stoke Therapeutics, Inc. [Member]                      
Other Commitments [Line Items]                      
Milestone payments payable     $ 907,500                
Stoke Therapeutics, Inc. [Member] | Research and Development [Member]                      
Other Commitments [Line Items]                      
Upfront consideration and transaction costs     $ 60,000                
Collaboration agreement description     For the SYNGAP1 program, the two companies will jointly share global research, development and commercialization responsibilities and share 50/50 in all worldwide costs and future profits                
License Agreements | North America                      
Other Commitments [Line Items]                      
Milestone payments payable           $ 40,000          
License Agreements | Neuren | North America                      
Other Commitments [Line Items]                      
Proceeds from Sale of Intangible Assets                 146,500    
Upfront payment   $ 100,000                  
Upfront license fee       $ 10,000              
Milestone payment as intangible asset           40,000          
PRV liability           $ 29,600     $ 19,200    
License Agreements | Neuren | Research and Development [Member] | North America                      
Other Commitments [Line Items]                      
Upfront payment             $ 10,000 $ 100,000      
License Agreements | Saniona                      
Other Commitments [Line Items]                      
Upfront payment $ 28,000                    
License Agreements | Saniona | Research and Development [Member]                      
Other Commitments [Line Items]                      
Upfront payment         28,000            
License Agreements | NNZ-2591 [Member] | Development Commercialization and Sales Milestones                      
Other Commitments [Line Items]                      
Milestone payments payable   831,300                  
Maximum                      
Other Commitments [Line Items]                      
Milestone payments payable         $ 3,900,000            
Maximum | License Agreements | Neuren | North America                      
Other Commitments [Line Items]                      
Milestone payments payable   $ 426,300   $ 455,000              
Maximum | License Agreements | Saniona                      
Other Commitments [Line Items]                      
Milestone payments payable 582,000                    
Maximum | License Agreements | Saniona | Development Commercialization and Sales Milestones                      
Other Commitments [Line Items]                      
Milestone payments payable 147,000                    
Maximum | License Agreements | Saniona | Sales                      
Other Commitments [Line Items]                      
Milestone payments payable $ 435,000