<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:5845b777-e955-4bf7-b4e5-3f0212c6bebe,g:62bde124-38c3-4298-bcdc-3cc4140b179e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.rocklandtrust.com/role/DEIDocument" xlink:type="simple" xlink:href="indb-20211110.xsd#DEIDocument"/>
  <link:definitionLink xlink:role="http://www.rocklandtrust.com/role/DEIDocument" xlink:type="extended" id="i0063bf15606e4457ae97966917dfec84_DEIDocument">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_49696893-6b8e-466b-9145-e0424d2b72db" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityEmergingGrowthCompany_49696893-6b8e-466b-9145-e0424d2b72db" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_997d5a2f-64db-4345-8309-20f44bf5e2b2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_Security12bTitle_997d5a2f-64db-4345-8309-20f44bf5e2b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_2f5beb95-e94f-4e43-be53-5431c43a5455" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityFileNumber_2f5beb95-e94f-4e43-be53-5431c43a5455" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_bb25c59d-5e72-4243-8f3d-336efe8b67ff" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityRegistrantName_bb25c59d-5e72-4243-8f3d-336efe8b67ff" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_32628269-0d0b-439d-b621-fbaec4b8acae" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_DocumentType_32628269-0d0b-439d-b621-fbaec4b8acae" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_a4ef4ce7-6600-40ff-9f81-50485aac6af3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_DocumentPeriodEndDate_a4ef4ce7-6600-40ff-9f81-50485aac6af3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_8a1a79bd-2687-4182-af64-dffb373df81b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityIncorporationStateCountryCode_8a1a79bd-2687-4182-af64-dffb373df81b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_39b64d69-2a72-4672-9d97-910f667f78be" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityTaxIdentificationNumber_39b64d69-2a72-4672-9d97-910f667f78be" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_8e01bac2-1f83-48be-8ed9-a1a86b34340a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_CityAreaCode_8e01bac2-1f83-48be-8ed9-a1a86b34340a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_66f19f59-fbe6-4eec-b53d-feb4cada2d29" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityAddressAddressLine1_66f19f59-fbe6-4eec-b53d-feb4cada2d29" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a01c6cbc-1258-4e3b-b574-de16f3957625" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityAddressCityOrTown_a01c6cbc-1258-4e3b-b574-de16f3957625" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_db952151-6b8e-4272-b2f7-d19fbf98e4f2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityAddressStateOrProvince_db952151-6b8e-4272-b2f7-d19fbf98e4f2" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_4a783829-00f8-46ce-856e-a90e37a9fd32" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityAddressPostalZipCode_4a783829-00f8-46ce-856e-a90e37a9fd32" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_69a9f06b-3c33-44b2-8e70-b5a8bd6c0e20" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_TradingSymbol_69a9f06b-3c33-44b2-8e70-b5a8bd6c0e20" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_c33dda76-229c-43fe-8853-6491bc8fbcc1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_SecurityExchangeName_c33dda76-229c-43fe-8853-6491bc8fbcc1" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_34b78ba0-de78-4bfa-a75a-e13830769e51" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_LocalPhoneNumber_34b78ba0-de78-4bfa-a75a-e13830769e51" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5daaeda4-c74f-4447-be21-100f9064c792" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntityCentralIndexKey_5daaeda4-c74f-4447-be21-100f9064c792" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_771b521b-5851-4c32-81f1-52b54e32faa3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_AmendmentFlag_771b521b-5851-4c32-81f1-52b54e32faa3" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_4e5be27f-234e-4822-894d-63d33fd43861" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_WrittenCommunications_4e5be27f-234e-4822-894d-63d33fd43861" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_908745be-d770-44e3-b510-bcbf58c5fffb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_SolicitingMaterial_908745be-d770-44e3-b510-bcbf58c5fffb" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_4af269a4-4451-473a-bf67-26eea5d55d06" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_4af269a4-4451-473a-bf67-26eea5d55d06" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_171c2df3-13ec-49b7-8047-bdd728420661" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_PreCommencementTenderOffer_171c2df3-13ec-49b7-8047-bdd728420661" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_06760a5c-08c6-49fc-905b-839beb0f8621" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_54997fbb-231e-47a1-b0f2-bd61b5bfb37d" xlink:to="loc_dei_EntitiesTable_06760a5c-08c6-49fc-905b-839beb0f8621" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_c59cafd5-5e8f-40bf-91c2-2b9c1632e804" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_06760a5c-08c6-49fc-905b-839beb0f8621" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_c59cafd5-5e8f-40bf-91c2-2b9c1632e804" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_c59cafd5-5e8f-40bf-91c2-2b9c1632e804_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_c59cafd5-5e8f-40bf-91c2-2b9c1632e804" xlink:to="loc_dei_AddressTypeDomain_c59cafd5-5e8f-40bf-91c2-2b9c1632e804_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_39855019-9664-4510-8d50-1f2f43200022" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_c59cafd5-5e8f-40bf-91c2-2b9c1632e804" xlink:to="loc_dei_AddressTypeDomain_39855019-9664-4510-8d50-1f2f43200022" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_MailingAddressMember_23c83437-2a44-45cd-bede-5f56d362e5fe" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_MailingAddressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_AddressTypeDomain_39855019-9664-4510-8d50-1f2f43200022" xlink:to="loc_dei_MailingAddressMember_23c83437-2a44-45cd-bede-5f56d362e5fe" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
