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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Operating activities      
Net income (loss) $ 11,420,000 $ (527,000) $ 9,715,000
Less: gain from discontinued operations 2,588,000 2,147,000 3,000
Income (loss) from continuing operations 8,832,000 (2,674,000) 9,712,000
Adjustments to reconcile net income (loss) to net cash used in operating activities:      
Write-off of acquired in-process research and development 480,000 0 2,282,000
Non-cash change in estimated fair value of contingent liabilities 3,597,000 1,650,000 1,888,000
Accretion of deferred gain on sale leaseback 0 0 (1,702,000)
Depreciation and amortization 2,663,000 2,727,000 2,790,000
Non-cash lease costs 0 0 (51,000)
Non-cash milestone revenue 0 (1,212,000) 0
Gain (loss) on asset disposal 5,000 (17,000) (456,000)
Stock-based compensation 5,666,000 4,067,000 3,351,000
Deferred income taxes 374,000 (1,204,000) (13,402,000)
Accretion of note payable 417,000 492,000 286,000
Other 0 0 5,000
Changes in operating assets and liabilities, net of acquisition:      
Accounts receivable, net 2,367,000 1,521,000 (3,915,000)
Inventory 646,000 1,030,000 1,114,000
Other current assets (130,000) 515,000 4,864,000
Other long term assets 218,000 334,000 605,000
Accounts payable and accrued liabilities (2,758,000) (4,801,000) (11,568,000)
Other liabilities (391,000) 484,000 865,000
Deferred revenue (654,000) (1,851,000) 2,160,000
Net cash provided by (used in) operating activities of continuing operations 21,332,000 1,061,000 (1,172,000)
Net cash used in operating activities of discontinued operations (642,000) (900,000) 0
Net cash provided by (used in) operating activities 20,690,000 161,000 (1,172,000)
Investing activities      
Purchase of commercial license rights (3,571,000) 0 0
Acquisition of CyDex, net of cash acquired 0 0 (32,024,000)
Payments to CVR holders (989,000) (8,049,000) (2,875,000)
Purchases of property, equipment and building (377,000) (595,000) (78,000)
Proceeds from sale of property, and equipment and building 3,000 20,000 530,000
Purchases of short-term investments 0 0 (10,000,000)
Proceeds from sale of short-term investments 0 10,000,000 19,346,000
Other, net (40,000) (113,000) (31,000)
Net cash (used in) provided by investing activities (4,974,000) 1,263,000 (25,132,000)
Financing activities      
Proceeds from issuance of debt 0 7,500,000 30,000,000
Repayment of debt (19,586,000) (10,000,000) 0
Proceeds from issuance of common stock, net 0 5,313,000 0
Net proceeds from stock option exercises 2,974,000 979,000 54,000
Net proceeds from employee stock purchase program 154,000 124,000 0
Share repurchases 0 0 (55,000)
Net cash (used in) provided by financing activities (16,458,000) 3,916,000 29,999,000
Net (decrease) increase in cash and cash equivalents (742,000) 5,340,000 3,695,000
Cash and cash equivalents at beginning of year 12,381,000 7,041,000 3,346,000
Cash and cash equivalents at end of year 11,639,000 12,381,000 7,041,000
Supplemental disclosure of cash flow information      
Interest paid 1,816,000 2,452,000 2,463,000
Taxes paid 26,000    39,000
Supplemental schedule of non-cash investing and financing activities      
Liability for commercial license rights 1,000,000 0 0
Accrued inventory purchases 341,000 1,426,000 0
Unrealized gain on AFS investments 2,914,000 0 0
Common stock released from restriction $ 0 $ 8,344,000 $ 0