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Basis of Presentation (Details Textual) (USD $) | 12 Months Ended |  | 12 Months Ended |  | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 12 Months Ended
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Dec. 31, 2013 segment | Dec. 31, 2012 | Dec. 31, 2011 | Apr. 30, 2013 program | Dec. 31, 2013 Stock Options 2002 Stock Incentive Plan | Dec. 31, 2013 Stock Options Vest 1/8 on the six month anniversary of the date of grant 2002 Stock Incentive Plan | Dec. 31, 2013 Stock Options Vest 1/48 each month for forty-two months 2002 Stock Incentive Plan | Dec. 31, 2013 Director 2002 Stock Incentive Plan | Dec. 31, 2013 Minimum | Dec. 31, 2013 Maximum | Dec. 31, 2013 Equipment Minimum | Dec. 31, 2013 Equipment Maximum | Dec. 31, 2013 CyDex | Dec. 31, 2012 CyDex | Dec. 31, 2011 CyDex | Jan. 31, 2011 CyDex | Jan. 31, 2012 CyDex Guaranteed Payment | Jan. 31, 2010 Metabasis Therapeutics right | Dec. 31, 2013 Metabasis Therapeutics | Dec. 31, 2012 Metabasis Therapeutics | Dec. 31, 2011 Metabasis Therapeutics | Apr. 30, 2013 Royalty Stream and Milestone Payments Purchase Agreement with Selexis | Dec. 31, 2013 Neurogen Corporation | Dec. 31, 2009 Neurogen Corporation right | Dec. 31, 2013 Neurogen Corporation VR1 | Dec. 31, 2011 IPR&D MEDI-528 | Dec. 31, 2011 IPR&D TRPV1 | Dec. 31, 2013 Customer Concentration Risk Accounts Receivable customer | Dec. 31, 2013 Major Customer 1 Customer Concentration Risk Accounts Receivable | Dec. 31, 2012 Major Customer 1 Customer Concentration Risk Accounts Receivable
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit | $ (671,339,000) | $ (682,759,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Working capital | (4,100,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period for which available resources are sufficient to satisfy company's anticipated operating and capital requirements | 12 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares excluded from computation | 800,000 | 1,100,000 | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity period of cash and cash equivalents, maximum | 3 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity period for short term investments, minimum | 3 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
FDIC insured amount | 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash deposits | 11,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, number of customers |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |
Concentration risk, percentage of accounts receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 75.00% | 87.00%
Reserve for obsolete inventory | 0 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable outstanding considered past due after period, minimum | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable outstanding considered past due after period, maximum | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allowance for doubtful accounts | 0 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  |  |  |  |  |  |  |  | 3 years | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation expense | 300,000 | 300,000 | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Definite lived intangibles, useful life | 20 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense | 2,400,000 | 2,400,000 | 2,300,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated amortization expense [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense 2014 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense 2015 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense 2016 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense 2017 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense 2018 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible assets with definite lives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 47,469,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business combination, weighted-average amortizaiton period intangible assets |  |  |  |  |  |  |  |  |  |  |  |  | 20 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
In-process research and development |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill | 12,238,000 | 12,238,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,538,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Acquisition of intellectual property |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,600,000 |  |  |  |  |  |  |  |
Gain (loss) on asset disposal | 5,000 | (17,000) | (456,000) |  |  |  |  |  |  |  |  |  | 500,000 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Impairment of IPR&D |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,100,000 | 1,200,000 |  |  |
Number of commercial license agreement programs |  |  |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,600,000 |  |  |  |  |  |  |  |
Cash payment due on first anniversary of the closing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000 |  |  |  |  |  |  |  |
Contingent value rights fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Paid to CyDex shareholders | 3,571,000 | 0 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Discounted to present value using a discount rate |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 21.60% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of contingent liability |  |  |  |  |  |  |  |  |  |  |  |  | 9,300,000 | 10,900,000 |  |  |  | 9,100,000 | 4,200,000 | 0 |  |  |  | 3,200,000 |  |  |  |  |  |
Contingent liability change in amount |  |  |  |  |  |  |  |  |  |  |  |  | 600,000 | (3,400,000) | 100,000 |  |  |  | (4,200,000) | 1,100,000 | (1,100,000) |  | 500,000 |  | 200,000 |  |  |  |  |
Contingent liability, cash payment |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000 | 8,000,000 | 2,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of contingent value rghts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  | 4 |  |  |  |  |  |
Number of contingent value rights per series of contingent value rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |
Number of series of contingent value rights issued per share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  |  |  |  |
Retirement of common stock held in treasury (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 months |  |  |  |  |  |  |  |  |  |  |  |
Retirement of treasury shares (in shares) | 1,118,222 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product sales reporting period |  |  |  |  |  |  |  |  | 30 days | 60 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period allowed for return of products, minimum | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period allowed for return of products, maximum | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue | $ 100,000 | $ 800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  | 6 months | 42 months | 1 year |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting right percentage |  |  |  |  |  | 12.50% | 2.08% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award expiration period |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of reportable segments | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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