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Basis of Presentation (Narrative) (Details) (USD $) | 3 Months Ended |  | 3 Months Ended | 1 Months Ended | 3 Months Ended |  |  | 1 Months Ended | 3 Months Ended | 1 Months Ended | 3 Months Ended |  | 3 Months Ended | 12 Months Ended | 3 Months Ended
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Mar. 31, 2014 segment drug | Mar. 31, 2013 | Dec. 31, 2013 | Mar. 31, 2014 Equipment Minimum | Mar. 31, 2014 Equipment Maximum | Apr. 30, 2013 Royalty Stream and Milestone Payments Purchase Agreement with Selexis program | Mar. 31, 2014 Cydex Pharmaceuticals, Inc | Mar. 31, 2013 Cydex Pharmaceuticals, Inc | Dec. 31, 2013 Cydex Pharmaceuticals, Inc | Jan. 31, 2011 Cydex Pharmaceuticals, Inc | Jan. 31, 2012 Cydex Pharmaceuticals, Inc Guaranteed Payment | Mar. 31, 2014 Cydex Pharmaceuticals, Inc Revenue Sharing | Mar. 31, 2013 Cydex Pharmaceuticals, Inc Revenue Sharing | Jan. 31, 2010 Metabasis Therapeutics right | Mar. 31, 2014 Metabasis Therapeutics | Mar. 31, 2013 Metabasis Therapeutics | Dec. 31, 2013 Metabasis Therapeutics | Mar. 31, 2014 Accounts Receivable Customer Concentration Risk customer | Dec. 31, 2013 Accounts Receivable Customer Concentration Risk customer | Mar. 31, 2014 Acquired In Process Research And Development | Mar. 31, 2013 Acquired In Process Research And Development
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit | $ 669,242,000 |  | $ 671,339,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Working capital | 12,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period for which available resources are sufficient to satisfy company's anticipated operating and capital requirements | 12 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Earnings (Loss) Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares excluded from computation | 1,000,000 | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash, Cash Equivalents and Short-term Investments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity period of cash and cash equivalents, maximum | 3 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity period of short term investments, minimum | 3 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentrations of Credit Risk |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
FDIC insured amount | 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash deposits | 12,300,000 |  | 11,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, number of customers |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 | 2 |  |
Concentration risk, percentage of accounts receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 65.00% | 75.00% |  |
Property and Equipment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated useful life of assets |  |  |  | 3 years | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation | 100,000 | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill and Other Identifiable Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible asset, useful life | 20 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense | 600,000 | 600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense 2014 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense 2015 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense 2016 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense 2017 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense 2018 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Acquired In-Process Research and Development |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Impairment of in-process research and development |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0
Commercial License Rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of commercial license agreement programs |  |  |  |  |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase price |  |  |  |  |  | 4,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments to acquire intangible assets |  |  |  |  |  | 3,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash payment due on first anniversary of the closing |  |  |  |  |  | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability |  |  |  |  |  |  |  |  |  | 17,600,000 |  |  |  |  |  |  |  |  |  |  |
Purchase of commercial license rights |  |  |  |  |  |  |  |  |  |  | 4,300,000 | 1,600,000 | 0 |  |  |  |  |  |  |  |
Fair value of liability |  |  |  |  |  |  | 7,200,000 |  | 9,300,000 |  |  |  |  |  | 6,700,000 |  | 4,200,000 |  |  |  |
Contingent liability change in amount |  |  |  |  |  |  | 500,000 | 1,800,000 |  |  |  |  |  |  | 2,500,000 | 0 |  |  |  |  |
Number of contingent value rights |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |
Number of contingent value rights per series of contingent value rights |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |
Number of contingent value rights issued for each share |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |
Contingent value rights, frequency of cash payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 months |  |  |  |  |  |  |
Revenue Recognition |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period allowed for return of products, minimum | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Period allowed for return of products, maximum | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Treasury stock, shares |  |  | 1,118,222 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allowance for Doubtful Accounts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable outstanding considered past due after period, minimum | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable outstanding considered past due after period, maximum | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allowance for doubtful accounts | 0 |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of Royalty Rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue | 0 |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Discontinued Operations |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of drugs included in product line | 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain on sale of Avinza Product Line before income taxes | $ 0 | $ 191,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Segment Reporting |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of reportable segments | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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