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Basis of Presentation (Details 5) (USD $) In Thousands, unless otherwise specified | 12 Months Ended
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Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | $ 11,270us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax | $ 5,666us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax | $ 4,067us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax
Research and development expenses |  |  |
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | 3,595us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember | 1,705us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember | 1,448us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember
General and administrative expenses |  |  |
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | $ 7,675us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember | $ 3,961us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember | $ 2,619us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember

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- Definition The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References No definition available. + Details
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