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Basis of Presentation (Details 5) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Basis of Presentation [Line Items]
Share-based compensation expense	$ 11,270us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax	$ 5,666us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax	$ 4,067us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax
Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	3,595us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember	1,705us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember	1,448us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember
General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 7,675us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember	$ 3,961us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember	$ 2,619us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember

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The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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