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Income Taxes (Details 1) (USD $)
In Thousands, unless otherwise specified
Dec. 31, 2014
Dec. 31, 2013
Deferred assets:    
Net operating loss carryforwards $ 193,747us-gaap_DeferredTaxAssetsOperatingLossCarryforwards $ 196,421us-gaap_DeferredTaxAssetsOperatingLossCarryforwards
Research and AMT credit carryforwards 28,288us-gaap_DeferredTaxAssetsTaxCreditCarryforwards 30,092us-gaap_DeferredTaxAssetsTaxCreditCarryforwards
Fixed assets and intangibles 13,237lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets 17,293lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets
Accrued expenses 1,579us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities 1,474us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
Contingent liabilities 579us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies 582us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies
Deferred revenue 771us-gaap_DeferredTaxAssetsDeferredIncome 760us-gaap_DeferredTaxAssetsDeferredIncome
Present value of royalties 11,686lgnd_DeferredTaxAssetsPresentValueOfRoyalties 12,175lgnd_DeferredTaxAssetsPresentValueOfRoyalties
Organon termination asset (111)lgnd_DeferredTaxAssetsTerminationAsset (4,073)lgnd_DeferredTaxAssetsTerminationAsset
Organon termination liability 111lgnd_DeferredTaxAssetsTerminationLiability 4,073lgnd_DeferredTaxAssetsTerminationLiability
Royalty obligation 0lgnd_DeferredTaxAssetsRoyaltyObligation 0lgnd_DeferredTaxAssetsRoyaltyObligation
Deferred rent 730us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent 1,634us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent
Lease termination costs 0lgnd_DeferredTaxAssetsLeaseTerminationCosts 0lgnd_DeferredTaxAssetsLeaseTerminationCosts
Capital loss carryforwards 0us-gaap_DeferredTaxAssetsCapitalLossCarryforwards 148us-gaap_DeferredTaxAssetsCapitalLossCarryforwards
Other 5,780us-gaap_DeferredTaxAssetsOther 3,701us-gaap_DeferredTaxAssetsOther
Deferred tax assets 256,397us-gaap_DeferredTaxAssetsGross 264,280us-gaap_DeferredTaxAssetsGross
Valuation allowance for deferred tax assets (240,420)us-gaap_DeferredTaxAssetsValuationAllowance (249,470)us-gaap_DeferredTaxAssetsValuationAllowance
Net deferred tax assets 15,977us-gaap_DeferredTaxAssetsNet 14,810us-gaap_DeferredTaxAssetsNet
Deferred tax liabilities:    
Retrophin fair value adjustment (1,396)lgnd_DeferredTaxLiabilitiesFairValueAdjustment (859)lgnd_DeferredTaxLiabilitiesFairValueAdjustment
Convertible debt (1,436)us-gaap_DeferredTaxLiabilitiesFinancingArrangements 0us-gaap_DeferredTaxLiabilitiesFinancingArrangements
Identified intangibles (13,146)lgnd_DeferredTaxLiabilitesFiniteLivedIntangibleAssets (13,984)lgnd_DeferredTaxLiabilitesFiniteLivedIntangibleAssets
Identified indefinite lived intangibles (3,048)lgnd_DeferredTaxLiabilitesIndefiniteLivedIntangibleAssets (2,639)lgnd_DeferredTaxLiabilitesIndefiniteLivedIntangibleAssets
Total $ (3,049)us-gaap_DeferredTaxLiabilities $ (2,672)us-gaap_DeferredTaxLiabilities