CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Operating activities
Net income (loss)	$ 10,892us-gaap_ProfitLoss	$ 11,420us-gaap_ProfitLoss	$ (527)us-gaap_ProfitLoss
Less: gain from discontinued operations	0	2,588	2,147
Income (loss) from continuing operations	10,892	8,832	(2,674)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Write-off of acquired in-process research and development	0us-gaap_ResearchAndDevelopmentInProcess	480us-gaap_ResearchAndDevelopmentInProcess	0us-gaap_ResearchAndDevelopmentInProcess
Change in estimated fair value of contingent liabilities	5,135	3,597	1,650
Realized gain on sale of short-term investment	(1,538)us-gaap_RealizedInvestmentGainsLosses	0us-gaap_RealizedInvestmentGainsLosses	0us-gaap_RealizedInvestmentGainsLosses
Depreciation and amortization	2,657	2,663	2,727
Amortization of debt discount and issuance fees	3,694	0	0
Non-cash milestone revenue	(1,211)lgnd_NonCashMilestone	0lgnd_NonCashMilestone	(1,212)lgnd_NonCashMilestone
(Gain) loss on asset disposal	(16)us-gaap_AssetImpairmentCharges	5us-gaap_AssetImpairmentCharges	(17)us-gaap_AssetImpairmentCharges
Stock-based compensation	11,270us-gaap_ShareBasedCompensation	5,666us-gaap_ShareBasedCompensation	4,067us-gaap_ShareBasedCompensation
Deferred income taxes	410	374	(1,204)
Accretion of note payable	222	417	492
Changes in operating assets and liabilities, net of acquisition:
Accounts receivable, net	(10,412)	2,367	1,521
Inventory	4,369us-gaap_IncreaseDecreaseInInventories	646us-gaap_IncreaseDecreaseInInventories	1,030us-gaap_IncreaseDecreaseInInventories
Other current assets	(426)	(130)	515
Other long term assets	(1,439)	218	334
Accounts payable and accrued liabilities	(3,155)	(2,758)	(4,801)
Other liabilities	34	(391)	484
Deferred revenue	80	(654)	(1,851)
Net cash provided by operating activities of continuing operations	20,566	21,332	1,061
Net cash used in operating activities of discontinued operations	0	(642)	(900)
Net cash provided by operating activities	20,566	20,690	161
Investing activities
Purchase of commercial license rights	(1,000)	(3,571)	0
Payments to CVR holders and other contingency payments	(3,493)	(989)	(8,049)
Purchases of property and equipment	(6)	(377)	(595)
Proceeds from sale of property and equipment	125	3	20
Proceeds from sale of short-term investments	2,342	0	10,000
Other, net	5	(40)	(113)
Net cash (used in) provided by investing activities	(2,027)	(4,974)	1,263
Financing activities
Proceeds from issuance of debt	0us-gaap_ProceedsFromIssuanceOfDebt	0us-gaap_ProceedsFromIssuanceOfDebt	7,500us-gaap_ProceedsFromIssuanceOfDebt
Repayment of debt	(9,366)us-gaap_RepaymentsOfLongTermDebt	(19,586)us-gaap_RepaymentsOfLongTermDebt	(10,000)us-gaap_RepaymentsOfLongTermDebt
Gross proceeds from issuance of 2019 Convertible Senior Notes	245,000us-gaap_ProceedsFromConvertibleDebt	0us-gaap_ProceedsFromConvertibleDebt	0us-gaap_ProceedsFromConvertibleDebt
Payment of debt issuance costs	(5,711)us-gaap_PaymentsOfDebtIssuanceCosts	0us-gaap_PaymentsOfDebtIssuanceCosts	0us-gaap_PaymentsOfDebtIssuanceCosts
Proceeds from issuance of warrants	11,638us-gaap_ProceedsFromIssuanceOfWarrants	0us-gaap_ProceedsFromIssuanceOfWarrants	0us-gaap_ProceedsFromIssuanceOfWarrants
Purchase of convertible bond hedge	(48,143)lgnd_PaymentsforConvertibleBondHedges	0lgnd_PaymentsforConvertibleBondHedges	0lgnd_PaymentsforConvertibleBondHedges
Proceeds from issuance of common stock, net	0	0	5,313
Net proceeds from stock option exercises	4,561	3,128	1,103
Share repurchases	(67,954)	0	0
Net cash (used in) provided by financing activities	130,025	(16,458)	3,916
Net (decrease) increase in cash and cash equivalents	148,564	(742)	5,340
Cash and cash equivalents at beginning of year	11,639	12,381	7,041
Cash and cash equivalents at end of year	160,203	11,639	12,381
Supplemental disclosure of cash flow information
Interest paid	494us-gaap_InterestPaid	1,816us-gaap_InterestPaid	2,452us-gaap_InterestPaid
Taxes paid	18us-gaap_IncomeTaxesPaid	26us-gaap_IncomeTaxesPaid	0us-gaap_IncomeTaxesPaid
Supplemental schedule of non-cash investing and financing activities
Accrued inventory purchases	3,246us-gaap_InventoryWriteDown	341us-gaap_InventoryWriteDown	1,426us-gaap_InventoryWriteDown
Unrealized gain on AFS investments	3,872us-gaap_UnrealizedGainLossOnInvestments	2,914us-gaap_UnrealizedGainLossOnInvestments	0us-gaap_UnrealizedGainLossOnInvestments
Common stock released from restriction	$ 0	$ 0	$ 8,344

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The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.

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The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder.

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The cash inflow from the additional capital contribution to the entity.

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The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt.

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No definition available.

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The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt).

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.

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-Glossary Investing Activities

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The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately.

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-Section 45

-Paragraph 14

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The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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-Name Accounting Standards Codification

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The net realized gains or losses on investments during the period, not including gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity.

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-Number 210

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-Paragraph 3

-Subparagraph a

-Article 7

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The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer.

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The amount of purchased research and development assets that are acquired in a business combination have no alternative future use and are therefore written off in the period of acquisition.

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The portion of the deferred gain that was recognized in the current period.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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Value of stock related to Restricted Stock Awards issued during the period, net of the stock value of such awards forfeited.

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-Publisher FASB

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The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period.

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