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Summary of Significant Accounting Policies (Details 5) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Basis of Presentation [Line Items]
Share-based compensation expense	$ 12,458	$ 11,270	$ 5,666
Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	4,080	3,595	1,705
General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 8,378	$ 7,675	$ 3,961

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