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Summary of Significant Accounting Policies (Details 5) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | $ 12,458 | $ 11,270 | $ 5,666
Research and development expenses |  |  |
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | 4,080 | 3,595 | 1,705
General and administrative expenses |  |  |
Basis of Presentation [Line Items] |  |  |
Share-based compensation expense | $ 8,378 | $ 7,675 | $ 3,961

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