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Investment in Viking (Details Textual)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 11 Months Ended 12 Months Ended
Jan. 01, 2016
USD ($)
May 31, 2015
USD ($)
$ / shares
shares
Apr. 30, 2015
May 31, 2014
USD ($)
program
May 04, 2015
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Sep. 30, 2015
Variable Interest Entity [Line Items]                  
Note receivable from Viking           $ 4,782      
Purchase of Viking common stock           9,000 $ 0 $ 0  
Investment in Viking           29,728      
Loss recorded (percent)         100.00%        
Gain on deconsolidation of Viking           28,190 0 0  
Equity in net losses from Viking           (5,143) 0 0  
Change in fair value of Viking convertible notes           (765) 0 0  
Variable Interest Entity, Primary Beneficiary                  
Variable Interest Entity [Line Items]                  
Number of programs licensed | program       5          
Amendment period     1 year            
Debt | Variable Interest Entity, Primary Beneficiary                  
Variable Interest Entity [Line Items]                  
Convertible loan facility extended       $ 2,500          
Interest rate (percent)       5.00%          
Repayment in equity (percent)     200.00%            
Common Stock                  
Variable Interest Entity [Line Items]                  
Aggregate value of shares received in Viking IPO   $ 29,200              
Shares of Viking stock purchased (shares) | shares   1.1              
Purchase of Viking common stock   $ 9,000              
Shares received pursuant to MLA amendment (shares) | shares   3.7              
Aggregate ownership, percent                 49.40%
IPO | Variable Interest Entity, Primary Beneficiary                  
Variable Interest Entity [Line Items]                  
Aggregate ownership after IPO (percent)     49.90%            
Viking Therapeutics, Inc.                  
Variable Interest Entity [Line Items]                  
Note receivable from Viking         $ 5,500        
Equity Method Investee                  
Variable Interest Entity [Line Items]                  
Investment in Viking         $ 34,900        
Equity Method Investee | Common Stock                  
Variable Interest Entity [Line Items]                  
Initial offering price per share (in usd per share) | $ / shares   $ 8.00              
Equity Method Investee | IPO | Common Stock                  
Variable Interest Entity [Line Items]                  
Shares sold in Viking IPO | shares   3.5              
Initial offering price per share (in usd per share) | $ / shares   $ 8.00              
Aggregate offering price   $ 27,600              
Metabasis Therapeutics                  
Variable Interest Entity [Line Items]                  
Contingent liability change in amount           1,200 $ (500) $ 4,200  
Metabasis Therapeutics | Scenario, Forecast                  
Variable Interest Entity [Line Items]                  
Contingent liability change in amount $ (2,600)                
Common Stock Received Pursuant to Master License Agreement | Metabasis Therapeutics                  
Variable Interest Entity [Line Items]                  
Contingent liability change in amount           $ 800