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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities      
Net income $ 227,444 $ 10,892 $ 11,420
Less: gain from discontinued operations 0 0 2,588
Income from continuing operations 227,444 10,892 8,832
Adjustments to reconcile net income to net cash used in operating activities:      
Write-off of acquired in-process research and development 0 0 480
Change in estimated fair value of contingent liabilities 5,013 5,135 3,597
Realized gain on sale of short-term investment (2,603) (1,538) 0
Depreciation and amortization 2,627 2,657 2,663
Gain on deconsolidation of Viking (28,190) 0 0
Loss on equity investment in Viking 5,143 0 0
Change in fair value of the convertible debt receivable from Viking 765 0 0
Amortization of debt discount and issuance fees 10,274 3,694 0
Non-cash milestone revenue 0 (1,211) 0
Stock-based compensation 12,458 11,270 5,666
Deferred income taxes (192,132) 410 374
Other 107 206 422
Changes in operating assets and liabilities, net of acquisition:      
Accounts receivable, net 6,489 (10,412) 2,367
Inventory (401) 4,369 646
Restricted cash 1,261 0 0
Other current assets 51 (426) (130)
Other long term assets (325) (1,439) 218
Accounts payable and accrued liabilities (4,027) (3,121) (3,149)
Deferred revenue (2,227) 80 (654)
Net cash provided by operating activities of continuing operations 41,727 20,566 21,332
Net cash used in operating activities of discontinued operations 0 0 (642)
Net cash provided by operating activities 41,727 20,566 20,690
Investing activities      
Purchase of commercial license rights (4,030) (1,000) (3,571)
Purchase of Viking common stock (9,000) 0 0
Reduction of cash due to deconsolidation of Viking (247) 0 0
Payments to CVR holders and other contingency payments (6,740) (3,493) (989)
Purchases of property and equipment (93) (6) (377)
Purchases of short-term investments (166,025) 0 0
Proceeds from sale of short-term investments 16,039 2,342 0
Proceeds from maturity of short-term investments 57,234 0 0
Other, net 0 130 (37)
Net cash used in investing activities (112,862) (2,027) (4,974)
Financing activities      
Repayment of debt 0 (9,366) (19,586)
Gross proceeds from issuance of 2019 Convertible Senior Notes 0 245,000 0
Payment of debt issuance costs 0 (5,711) 0
Proceeds from issuance of warrants 0 11,638 0
Purchase of convertible bond hedge 0 (48,143) 0
Net proceeds from stock option exercises 8,849 4,561 3,128
Share repurchases (489) (67,954) 0
Net cash provided by (used in) financing activities 8,360 130,025 (16,458)
Net (decrease) increase in cash and cash equivalents (62,775) 148,564 (742)
Cash and cash equivalents at beginning of year 160,203 11,639 12,381
Cash and cash equivalents at end of year 97,428 160,203 11,639
Supplemental disclosure of cash flow information      
Interest paid 1,822 494 1,816
Taxes paid 28 18 26
Supplemental schedule of non-cash investing and financing activities      
Accrued inventory purchases 1,333 3,246 341
Unrealized gain on AFS investments $ 3,005 $ 3,872 $ 2,914