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Fair Value Measurements (Details) - USD ($) | 6 Months Ended |  |
--- | --- | --- | ---
Jun. 30, 2016 | Dec. 31, 2015 | Aug. 31, 2014
2019 convertible senior notes |  |  |
Liabilities: |  |  |
Principal amount outstanding | $ 245,000,000 | $ 245,000,000 |
2019 convertible senior notes | Senior Notes |  |  |
Liabilities: |  |  |
Principal amount outstanding |  |  | $ 245,000,000.0
Estimated fair value of debt | 408,500,000 |  |
Recurring |  |  |
Assets: |  |  |
Assets, fair value | 48,647,000 | 100,572,000 |
Liabilities: |  |  |
Liabilities, fair value | 10,086,000 | 14,241,000 |
Recurring | Current contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 5,337,000 | 7,812,000 |
Recurring | Current contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value |  | 2,602,000 |
Recurring | Long-term contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value | 2,504,000 | 1,355,000 |
Recurring | Long-term contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 1,634,000 | 1,678,000 |
Recurring | Liability for amounts owed to former licensees |  |  |
Liabilities: |  |  |
Liabilities, fair value | 611,000 | 794,000 |
Recurring | Cash Equivalents |  |  |
Assets: |  |  |
Assets, fair value |  | 3,015,000 |
Recurring | Short-term investments |  |  |
Assets: |  |  |
Assets, fair value | $ 44,908,000 | 92,775,000 |
Recurring | Note receivable Viking Therapeutics, Inc. |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Estimated volatility of common stock | 50.00% |  |
Assets: |  |  |
Assets, fair value | $ 3,207,000 | 4,782,000 |
Recurring | Investment in warrants |  |  |
Assets: |  |  |
Assets, fair value | 532,000 |  |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) |  |  |
Assets: |  |  |
Assets, fair value | 5,361,000 | 6,786,000 |
Liabilities: |  |  |
Liabilities, fair value | 611,000 | 794,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Current contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Current contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value |  | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Long-term contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Long-term contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for amounts owed to former licensees |  |  |
Liabilities: |  |  |
Liabilities, fair value | 611,000 | 794,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Cash Equivalents |  |  |
Assets: |  |  |
Assets, fair value |  | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments |  |  |
Assets: |  |  |
Assets, fair value | 4,829,000 | 6,786,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Note receivable Viking Therapeutics, Inc. |  |  |
Assets: |  |  |
Assets, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in warrants |  |  |
Assets: |  |  |
Assets, fair value | 532,000 |  |
Recurring | Significant Other Observable Inputs (Level 2) |  |  |
Assets: |  |  |
Assets, fair value | 40,079,000 | 89,004,000 |
Liabilities: |  |  |
Liabilities, fair value | 2,504,000 | 3,957,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Current contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Current contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value |  | 2,602,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Long-term contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value | 2,504,000 | 1,355,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Long-term contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Liability for amounts owed to former licensees |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Cash Equivalents |  |  |
Assets: |  |  |
Assets, fair value |  | 3,015,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments |  |  |
Assets: |  |  |
Assets, fair value | 40,079,000 | 85,989,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Note receivable Viking Therapeutics, Inc. |  |  |
Assets: |  |  |
Assets, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Investment in warrants |  |  |
Assets: |  |  |
Assets, fair value | 0 |  |
Recurring | Significant Unobservable Inputs (Level 3) |  |  |
Assets: |  |  |
Assets, fair value | 3,207,000 | 4,782,000 |
Liabilities: |  |  |
Liabilities, fair value | 6,971,000 | 9,490,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Current contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 5,337,000 | 7,812,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Current contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value |  | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Long-term contingent liabilities-Metabasis |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Long-term contingent liabilities-CyDex |  |  |
Liabilities: |  |  |
Liabilities, fair value | 1,634,000 | 1,678,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Liability for amounts owed to former licensees |  |  |
Liabilities: |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Cash Equivalents |  |  |
Assets: |  |  |
Assets, fair value |  | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments |  |  |
Assets: |  |  |
Assets, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Note receivable Viking Therapeutics, Inc. |  |  |
Assets: |  |  |
Assets, fair value | 3,207,000 | $ 4,782,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Investment in warrants |  |  |
Assets: |  |  |
Assets, fair value | 0 |  |
Viking Therapeutics, Inc. |  |  |
Liabilities: |  |  |
Market value of investment in Viking | $ 7,900,000 |  |

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