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Summary of Significant Accounting Policies (Details Textual) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Jan. 31, 2010 right
Basis of Presentation [Line Items] |  |  |  |
Working capital deficit | $ 64,100,000 |  |  |
Mezzanine equity excluded from working capital deficit | $ 30,000,000 |  |  |
Days after threshold consecutive trading days to complete payment of principal | 3 days |  |  |
Number of consecutive trading days | 50 days |  |  |
Maturity period of cash and cash equivalents, maximum | 3 months |  |  |
Write-downs related to obsolete inventory | $ 0 | $ 0 |  |
Goodwill impairment | 0 |  |  |
Royalty revenue | 59,423,000 | 38,194,000 | $ 29,994,000 |
Accounts receivable, net | $ 14,700,000 | 6,170,000 |  |
Restocking fee (percent) | 20.00% |  |  |
Share-based Compensation [Abstract] |  |  |  |
Expected dividend rate (percent) | 0.00% |  |  |
Gain on disposition of product line | $ 1,100,000 |  |  |
Provision for taxes on gain | $ 408,000 | $ 0 | $ 0 |
Stock Options | 2002 Stock Incentive Plan |  |  |  |
Share-based Compensation [Abstract] |  |  |  |
Award expiration period | 10 years |  |  |
Stock Options | Vest 1/8 on the six month anniversary of the date of grant | 2002 Stock Incentive Plan |  |  |  |
Share-based Compensation [Abstract] |  |  |  |
Award vesting period | 6 months |  |  |
Award vesting right percentage | 12.50% |  |  |
Stock Options | Vest 1/48 each month for forty-two months | 2002 Stock Incentive Plan |  |  |  |
Share-based Compensation [Abstract] |  |  |  |
Award vesting period | 42 months |  |  |
Award vesting right percentage | 2.08% |  |  |
Director |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Mr. Aryeh's ownership percentage in CorMatrix (percent, less than) | 1.00% |  |  |
Director | 2002 Stock Incentive Plan |  |  |  |
Share-based Compensation [Abstract] |  |  |  |
Award vesting period | 1 year |  |  |
Minimum |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Property and equipment, useful life | 3 years |  |  |
Sales/revenues from partners reporting period | 30 days |  |  |
Maximum |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Property and equipment, useful life | 10 years |  |  |
Sales/revenues from partners reporting period | 60 days |  |  |
Metabasis Therapeutics |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Number of contingent value rights | right |  |  |  | 4
IPR&D |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Impairment charge | $ 0 |  |  |
CorMatrix |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Royalty revenue | 1,500,000 |  |  |
Accounts receivable, net | $ 200,000 |  |  |

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