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Stockholders' Equity - Share-base Compensation (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | $ 18,893 | $ 12,458 | $ 11,270
Research and development expenses |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | 8,836 | 4,080 | 3,595
General and administrative expenses |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | $ 10,057 | $ 8,378 | $ 7,675

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- Definition The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References No definition available. + Details
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