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Investment in Viking (Details Textual) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended | 13 Months Ended |
--- | --- | --- | --- | --- | ---
Apr. 13, 2016 USD ($) shares | Apr. 30, 2016 USD ($) $ / shares shares | Jan. 31, 2016 USD ($) | May 31, 2015 USD ($) $ / shares shares | Apr. 30, 2015 | May 31, 2014 USD ($) program | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | May 31, 2015 $ / shares | Aug. 31, 2014 $ / shares shares
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase number of shares (shares) | shares |  |  |  |  |  |  |  |  |  |  | 3,264,643
Exercise price per share of warrants (in USD per share) | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 125.08
Proceeds received from repayment of Viking note receivable |  |  |  |  |  |  | $ 300 | $ 0 | $ 0 |  |
Note receivable from Viking |  |  |  |  |  |  | $ 3,207 | $ 4,782 |  |  |
Viking |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of programs licensed | program |  |  |  |  |  | 5 |  |  |  |  |
Loss recorded (percent) |  |  |  |  |  |  |  |  |  | 100.00% |
Debt | Viking |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Convertible loan facility extended |  |  |  |  |  | $ 2,500 |  |  |  |  |
Repayment in equity (percent) |  |  |  |  | 200.00% |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Aggregate value of shares received in Viking IPO |  |  |  | $ 29,200 |  |  |  |  |  |  |
Shares of Viking stock purchased (shares) | shares |  |  |  | 1,100,000 |  |  |  |  |  |  |
Purchase of Viking common stock |  |  |  | $ 9,000 |  |  |  |  |  |  |
Equity Method Investee |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Shares sold in Viking IPO (shares) | shares |  | 7,500,000 |  |  |  |  |  |  |  |  |
Initial offering price per share (in usd per share) | $ / shares |  | $ 1.25 |  |  |  |  |  |  |  |  |
Shares of Viking stock purchased (shares) | shares |  | 560,000 |  |  |  |  |  |  |  |  |
Purchase of Viking common stock |  | $ 700 |  |  |  |  |  |  |  |  |
Interest rate on note due from Viking (percent) |  |  | 2.50% |  |  |  |  | 5.00% |  |  |
Extension of lock-up period |  |  | 1 year |  |  |  |  |  |  |  |
Amount of loan to be repaid upon consummation of first capital financing transaction |  |  | $ 1,500 |  |  |  |  |  |  |  |
Amount of loan to be repaid in cash upon consummation of first capital financing transaction |  |  | $ 300 |  |  |  |  |  |  |  |
Warrants to purchase number of shares (shares) | shares |  | 7,500,000 |  |  |  |  |  |  |  |  |
Exercise price per share of warrants (in USD per share) | $ / shares |  | $ 1.50 |  |  |  |  |  |  |  |  |
Warrants purchased (shares) | shares |  | 560,000 |  |  |  |  |  |  |  |  |
Proceeds received from repayment of Viking note receivable | $ 300 |  |  |  |  |  |  |  |  |  |
Shares received pursuant to MLA amendment (shares) | shares | 960,000 |  |  |  |  |  |  |  |  |  |
Warrants received, licensing agreement (shares) | shares | 960,000 |  |  |  |  |  |  |  |  |  |
Value of consideration received for repayment of convertible notes | $ 1,200 |  |  |  |  |  |  |  |  |  |
Aggregate ownership, percent |  | 32.70% |  |  |  |  | 30.30% |  |  |  |
Decrease in equity method investment |  | $ (10,700) |  |  |  |  |  |  |  |  |
Other than temporary impairment of investment in Viking |  |  |  |  |  |  | $ 7,400 |  |  |  |
Equity Method Investee | IPO | Common Stock |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Shares sold in Viking IPO (shares) | shares |  |  |  | 3,700,000 |  |  |  |  |  |  |
Aggregate offering price |  |  |  | $ 29,200 |  |  |  |  |  |  |
Initial offering price per share (in usd per share) | $ / shares |  |  |  | $ 8.00 |  |  |  |  |  | $ 8.00 |

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