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Basis of Presentation and Summary of Significant Accounting Policies (Accounting for Share-Based Compensation) (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Basis of Presentation [Line Items]        
Share-based compensation expense total $ 5,248 $ 5,331 $ 15,917 $ 13,690
Research and development expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense total 2,394 2,845 8,260 6,112
General and administrative expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense total $ 2,854 $ 2,486 $ 7,657 $ 7,578