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Basis of Presentation and Summary of Significant Accounting Policies (Tables)
 3 Months Ended
Mar. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of Revenue by Source
The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands):

 
 
Three months ended
 
 
March 31,
 
 
2018
 
2017
Material Sales
 
 
 
 
Captisol
$
4,391

 
$
1,121

License fees, milestones and other
 
 
 
 
License Fees
$
26,955

 
$
2,872

 
Milestone
2,825

 
1,008

 
Other
1,166

 
36

 
 
$
30,946

 
$
3,916
Schedule of Investment Categories
The Company's investments consist of the following at March 31, 2018 and December 31, 2017 (in thousands):
 
March 31, 2018
 
December 31, 2017
 
Amortized cost
 
Gross unrealized
gains
 
Gross unrealized
losses
 
Estimated
fair value
 
Amortized cost
 
Gross unrealized
gains
 
Gross unrealized
losses
 
Estimated
fair value
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Short-term investments
 
 
 
 
 
 


 
 
 
 
 
 
 
 
     Bank deposits
$
94,855

 
$
5

 
$
(97
)
 
$
94,763

 
$
80,095

 
$
6

 
$
(42
)
 
$
80,059

     Corporate bonds
73,129

 
—

 
(216
)
 
72,913

 
55,335

 
—

 
(96
)
 
55,239

     Commercial paper
29,977

 
—

 
(26
)
 
29,951

 
27,933

 
—

 
(20
)
 
27,913

     U.S. Government bonds
11,964

 
—

 
(22
)
 
11,942

 
8,939

 
—

 
(10
)
 
8,929

     Agency bonds
—

 
—

 
—

 
—

 
4,991

 
—

 
(1
)
 
4,990

     Municipal bonds
2,014

 
—

 
(12
)
 
2,002

 
2,028

 
—

 
(13
)
 
2,015

     Corporate equity securities
181

 
1,577

 
—

 
1,758

 
207

 
1,689

 
—

 
1,896

 
$
212,120

 
$
1,582

 
$
(373
)
 
$
213,329

 
$
179,528

 
$
1,695

 
$
(182
)
 
$
181,041
Schedule of Goodwill and Other Identifiable Intangible Assets
Goodwill and other identifiable intangible assets consist of the following (in thousands):
 
March 31,
 
December 31,
 
2018
 
2017
Indefinite lived intangible assets
 
 
 
     IPR&D
$
2,410

 
$
7,923

     Goodwill
85,961

 
85,959

Definite lived intangible assets
 
 
 
     Complete technology
228,413

 
222,900

          Less: Accumulated amortization
(26,176
)
 
(23,301
)
     Trade name
2,642

 
2,642

          Less: Accumulated amortization
(949
)
 
(916
)
     Customer relationships
29,600

 
29,600

          Less: Accumulated amortization
(10,634
)
 
(10,264
)
Total goodwill and other identifiable intangible assets, net
$
311,267

 
$
314,543
Schedule of Commercial License Rights
Commercial license rights consist of the following (in thousands):

 
March 31,
 
December 31,
 
2018
 
2017
Aziyo and CorMatrix
$
17,696

 
$
17,696

Selexis
8,602

 
8,602

 
$
26,298

 
$
26,298

Less: accumulated amortization
(6,329
)
 
(6,772
)
   Total commercial rights, net
$
19,969

 
$
19,526
Schedule of Accrued Liabilities
Accrued liabilities consist of the following (in thousands):
 
 
March 31,
 
December 31,
 
 
2018
 
2017
Compensation
 
$
1,455

 
$
4,085

Professional fees
 
497

 
430

Amounts owed to former licensees
 
3,417

 
396

Royalties owed to third parties
 
1,043

 
954

Deferred revenue
 
75

 
173

Other
 
1,993

 
1,339

     Total accrued liabilities
 
$
8,480

 
$
7,377
Schedule of Accounting for Share-Based Compensation
The following table summarizes stock-based compensation expense recorded as components of research and development expenses and general and administrative expenses for the periods indicated (in thousands):
 
Three months ended
 
March 31,
 
2018
 
2017
Stock-based compensation expense as a component of:
 
 
 
Research and development expenses
$
1,767

 
$
3,939

General and administrative expenses
2,788

 
2,106

 
$
4,555

 
$
6,045
Schedule of Fair-Value Options Awarded to Employees and Directors
The fair-value for options that were awarded to employees and directors was estimated at the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions:
 
Three months ended
 
March 31,
 
2018
 
2017
Risk-free interest rate
2.7%
 
2.1%
Dividend yield
—
 
—
Expected volatility
33%
 
47%
Expected term
5.7
 
6.9
Schedule of Computation of Basic and Diluted Net Income (Loss) per Share
The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:
 
Three months ended
 
March 31,
 
2018
 
2017
Weighted average shares outstanding:
21,208,793

 
20,937,627

Dilutive potential common shares:
 
 
 
Restricted stock
63,959

 
185,745

     Stock options
1,119,611

 
954,509

     2019 Convertible Senior Notes
1,719,099

 
941,308

     Warrants
688,852

 
—

Shares used to compute diluted income per share
24,800,314

 
23,019,189

Potentially dilutive shares excluded from calculation due to anti-dilutive effect
148,404

 
3,711,067