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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Basis of Presentation [Line Items]
Share-based compensation expense	$ 4,555	$ 6,045
Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	1,767	3,939
General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 2,788	$ 2,106

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- Definition

Basis of presentation.

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- Definition

The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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No definition available.

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