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Fair Value Measurements - Assets and Liabilities at Fair Value (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Recurring
Assets:
Assets, fair value	$ 249,335	$ 188,764
Liabilities:
Liabilities, fair value	10,343	14,245
Recurring | Current contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	3,618	4,618
Recurring | Current contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	86	86
Recurring | Long-term contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	3,783	3,783
Recurring | Long-term contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	1,503	1,503
Recurring | Long-term contingent liabilities-Metabasis
Liabilities:
Liabilities, fair value	1,089	3,971
Recurring | Liability for amounts owed to former licensees
Liabilities:
Liabilities, fair value	264	284
Recurring | Short-term investments
Assets:
Assets, fair value	240,864	181,041
Recurring | Note Receivable - Viking Therapeutics
Assets:
Assets, fair value	3,877	3,877
Recurring | Investment in Warrants
Assets:
Assets, fair value	4,594	3,846
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)
Assets:
Assets, fair value	33,886	5,742
Liabilities:
Liabilities, fair value	264	284
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Current contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Current contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Long-term contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Long-term contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Long-term contingent liabilities-Metabasis
Liabilities:
Liabilities, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for amounts owed to former licensees
Liabilities:
Liabilities, fair value	264	284
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments
Assets:
Assets, fair value	29,292	1,896
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Note Receivable - Viking Therapeutics
Assets:
Assets, fair value	0	0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in Warrants
Assets:
Assets, fair value	4,594	3,846
Recurring | Significant Other Observable Inputs (Level 2)
Assets:
Assets, fair value	211,572	179,145
Liabilities:
Liabilities, fair value	1,089	3,971
Recurring | Significant Other Observable Inputs (Level 2) | Current contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Current contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Long-term contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Long-term contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Long-term contingent liabilities-Metabasis
Liabilities:
Liabilities, fair value	1,089	3,971
Recurring | Significant Other Observable Inputs (Level 2) | Liability for amounts owed to former licensees
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments
Assets:
Assets, fair value	211,572	179,145
Recurring | Significant Other Observable Inputs (Level 2) | Note Receivable - Viking Therapeutics
Assets:
Assets, fair value	0	0
Recurring | Significant Other Observable Inputs (Level 2) | Investment in Warrants
Assets:
Assets, fair value	0	0
Recurring | Significant Unobservable Inputs (Level 3)
Assets:
Assets, fair value	3,877	3,877
Liabilities:
Liabilities, fair value	8,990	9,990
Recurring | Significant Unobservable Inputs (Level 3) | Current contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	3,618	4,618
Recurring | Significant Unobservable Inputs (Level 3) | Current contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	86	86
Recurring | Significant Unobservable Inputs (Level 3) | Long-term contingent liabilities - Crystal
Liabilities:
Liabilities, fair value	3,783	3,783
Recurring | Significant Unobservable Inputs (Level 3) | Long-term contingent liabilities - CyDex
Liabilities:
Liabilities, fair value	1,503	1,503
Recurring | Significant Unobservable Inputs (Level 3) | Long-term contingent liabilities-Metabasis
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Unobservable Inputs (Level 3) | Liability for amounts owed to former licensees
Liabilities:
Liabilities, fair value	0	0
Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments
Assets:
Assets, fair value	0	0
Recurring | Significant Unobservable Inputs (Level 3) | Note Receivable - Viking Therapeutics
Assets:
Assets, fair value	3,877	3,877
Recurring | Significant Unobservable Inputs (Level 3) | Investment in Warrants
Assets:
Assets, fair value	0	$ 0
Metabasis | Long-term contingent liabilities-Metabasis
Liabilities:
CVR payable to Metabasis	$ 3,800

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- Definition

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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-Topic 820
-SubTopic 10
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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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