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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Operating activities    
Net income $ 45,279 $ 5,079
Adjustments to reconcile net income to net cash provided by operating activities:    
Non-cash change in estimated fair value of contingent liabilities 960 140
Depreciation and amortization 3,002 2,979
Amortization of debt discount and issuance fees 3,018 2,838
Stock-based compensation 4,555 6,045
Deferred income taxes 9,862 1,018
Change in fair value of the Viking convertible debt receivable and warrants (748) (76)
(Gain) / loss from equity investments (21,183) 1,083
Changes in operating assets and liabilities:    
Payments to CVR holders and other contingency payments 0 (4,998)
Royalties recorded in retained earnings upon adoption of ASU 606 32,707 0
Accounts receivable (11,512) 7,643
Inventory (4,978) (1,197)
Accounts payable and accrued liabilities 321 (1,963)
Other (522) 633
Net cash provided by operating activities 60,761 19,224
Investing activities    
Payments to CVR holders and other contingency payments (1,000) 0
Purchase of short-term investments (98,957) (73,352)
Proceeds from sale of short-term investments 12,291 17,719
Proceeds from maturity of short-term investments 54,325 30,052
Other (240) (87)
Net cash used in investing activities (33,581) (25,668)
Financing activities    
Net proceeds from stock option exercises and ESPP 8,916 355
Taxes paid related to net share settlement of equity awards (3,797) (2,022)
Share repurchase (1,895) 0
Net cash provided by (used in) provided by financing activities 3,224 (1,667)
Net increase (decrease) in cash and cash equivalents 30,404 (8,111)
Cash and cash equivalents at beginning of period 20,620 18,752
Cash and cash equivalents at end of period 51,024 10,641
Supplemental disclosure of cash flow information    
Interest paid 919 919
Taxes paid 171 96
Supplemental schedule of non-cash activity    
Accrued inventory purchases 1,180 3,909
Unrealized gain (loss) on AFS investments $ 0 $ (66)