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Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | Mar. 31, 2018 | Dec. 31, 2017
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments |  |  |  | $ 0 | $ 24 |  |
Total revenue |  | $ 90,043 | $ 27,995 | 146,200 | 57,264 |  |
Decrease in accumulated deficit |  | (254,240) |  | (254,240) |  |  | $ (400,924)
Operating income (loss) |  | 70,175 | 13,015 | 107,216 | 23,233 |  |
Milestone payment received |  |  |  | 4,600 |  |  |
Third-party in-licensor portion of milestone payment received |  |  |  | 3,000 |  |  |
Revenue recognized from milestone method revenue |  |  |  | 1,600 |  |  |
Gain (loss) from Viking |  | 39,963 | (1,400) | 61,808 | (2,406) |  |
Assets, fair value |  | 877,560 |  | 877,560 |  |  | 188,764
Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 12,296 |  | 12,296 |  |  | 3,846
Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 3,877
Level 1 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 73,689 |  | 73,689 |  |  | 5,742
Level 1 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 12,296 |  | 12,296 |  |  | 3,846
Level 1 | Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 0
Level 3 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 3,877
Level 3 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 0
Level 3 | Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 3,877
Viking Therapeutics, Inc. |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments |  | 32,300 |  | 53,500 |  |  |
Equity method investment, ownership (percent) |  |  |  |  |  | 12.40% |
Market value of investment in Viking |  | $ 59,800 |  | $ 59,800 |  |  |
Outstanding warrants to purchase shares of Viking's common stock (shares) |  | 1.5 |  | 1.5 |  |  |
Warrant exercise price (USD per share) |  | $ 1.50 |  | $ 1.50 |  |  |
Recurring | Level 1 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | $ 12,300 |  | $ 12,300 |  |  | $ 3,800
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | (10,400) |  | $ (1,500) |  |  |
Decrease in accumulated deficit | $ 25,400 |  |  |  |  |  |
Operating income (loss) | (11,900) |  |  |  |  |  |
Accumulated Other Comprehensive Income | Accounting Standards Update 2016-01 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments | 2,600 |  |  |  |  |  |
Retained Earnings | Accounting Standards Update 2016-01 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments | $ 2,600 |  |  |  |  |  |
Royalty Agreements | Aziyo |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Effective interest rate for forecasted cash flows (as a percent) |  |  |  | 26.00% |  |  |
Royalty [Member] |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 31,396 | 14,211 | $ 52,216 | 38,441 |  |
Royalty [Member] | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 21,100 | 14,200 |  | 38,400 |  |
Promacta |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 24,800 |  | 40,400 |  |  |
Promacta | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 15,600 | 9,700 |  | 26,400 |  |
Kyprolis |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 4,700 |  | 8,100 |  |  |
Kyprolis | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 3,400 | 2,900 |  | 7,500 |  |
Evomela |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 1,200 |  | 2,800 |  |  |
Evomela | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 1,600 | 1,300 |  | 3,100 |  |
Other |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 700 |  | $ 900 |  |  |
Other | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | $ 500 | $ 300 |  | $ 1,400 |  |

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