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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Basis of Presentation [Line Items]
Share-based compensation expense	$ 4,812	$ 4,624	$ 9,367	$ 10,669
Research and development expenses
Basis of Presentation [Line Items]
Share-based compensation expense	2,096	1,928	3,863	5,867
General and administrative expenses
Basis of Presentation [Line Items]
Share-based compensation expense	$ 2,716	$ 2,696	$ 5,504	$ 4,802

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Basis of presentation.

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The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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No definition available.

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