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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities    
Net income $ 118,441 $ 11,137
Adjustments to reconcile net income to net cash provided by operating activities:    
Non-cash change in estimated fair value of contingent liabilities 2,730 966
Payments to CVR holders and other contingent payments 0 (4,998)
Depreciation and amortization 6,013 5,564
Amortization of debt discount and issuance fees 15,455 5,720
Stock-based compensation 9,367 10,669
Deferred income taxes 32,263 3,224
Change in fair value of the Viking convertible debt receivable and warrants (8,450) 77
(Gain) / loss from equity investments (53,689) 2,330
Royalties recorded in retained earnings upon adoption of ASU 606 32,707 0
Changes in operating assets and liabilities:    
Accounts receivable (16,405) 1,263
Inventory (4,395) (4,286)
Accounts payable, accrued liabilities and Other 368 (2,056)
Net cash provided by operating activities 134,405 29,610
Investing activities    
Payments to CVR holders and other contingency payments (1,000) 0
Purchase of short-term investments (745,783) (124,282)
Proceeds received from repayment of Viking note receivable 3,914 0
Proceeds received from repayment of commercial license rights 0 2,859
Proceeds from sale of short-term investments 12,791 83,268
Proceeds from maturity of short-term investments 110,175 51,887
Other (416) (199)
Net cash (used in) provided by investing activities (620,319) 13,533
Financing activities    
Repayment of debt (21,785) 0
Gross proceeds from issuance of 2023 Convertible Senior Notes 750,000 0
Payment of debt issuance costs (16,900) 0
Proceeds from issuance of warrants 90,000 0
Purchase of convertible bond hedge (140,250) 0
Net proceeds from stock option exercises and ESPP 11,849 2,370
Taxes paid related to net share settlement of equity awards (3,434) (4,042)
Share repurchase (52,727) 0
Net cash provided by (used in) provided by financing activities 616,753 (1,672)
Net increase in cash and cash equivalents 130,839 41,471
Cash and cash equivalents at beginning of period 20,620 18,752
Cash and cash equivalents at end of period 151,459 60,223
Supplemental disclosure of cash flow information    
Interest paid 919 919
Taxes paid 285 132
Supplemental schedule of non-cash activity    
Accrued fixed asset purchases 66 0
Accrued inventory purchases 752 0
Unrealized gain on AFS investments 0 24
Excess of conversion value over the principal amount of 2019 Notes paid in shares (31,571) 0
Value of shares reacquired under convertible bond hedge transaction entered into with 2019 Notes $ 31,571 $ 0