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Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Mar. 31, 2018 | Dec. 31, 2017
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments |  |  |  | $ 0 | $ 628 |  |
Total revenue |  | $ 45,663 | $ 33,375 | 191,863 | 90,638 |  |
Decrease in accumulated deficit |  | (183,914) |  | (183,914) |  |  | $ (400,924)
Operating income (loss) |  | 23,362 | 16,493 | 130,578 | 39,726 |  |
Milestone payment received |  |  |  | 4,600 |  |  |
Third-party in-licensor portion of milestone payment received |  |  |  | 3,000 |  |  |
Revenue recognized from milestone method revenue |  |  |  | 1,600 |  |  |
Gain (loss) from Viking |  | 62,398 | (1,019) | 124,206 | (3,350) |  |
Assets, fair value |  | 1,020,595 |  | 1,020,595 |  |  | 188,764
Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 24,284 |  | 24,284 |  |  | 3,846
Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 3,877
Level 1 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 131,150 |  | 131,150 |  |  | 5,742
Level 1 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 24,284 |  | 24,284 |  |  | 3,846
Level 1 | Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 0
Level 3 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 3,877
Level 3 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | 0 |  | 0 |  |  | 0
Level 3 | Note Receivable - Viking Therapeutics |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | $ 0 |  | $ 0 |  |  | 3,877
Viking Therapeutics, Inc. |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Equity method investment, ownership (percent) |  |  |  |  |  | 12.40% |
Outstanding warrants to purchase shares of Viking's common stock (shares) |  | 1.5 |  | 1.5 |  |  |
Warrant exercise price (USD per share) |  | $ 1.50 |  | $ 1.50 |  |  |
Recurring | Level 1 | Investment in Warrants |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Assets, fair value |  | $ 24,300 |  | $ 24,300 |  |  | $ 3,800
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Decrease in accumulated deficit | $ 25,400 |  |  |  |  |  |
Operating income (loss) | (11,900) |  |  |  |  |  |
Accumulated Other Comprehensive Income | Accounting Standards Update 2016-01 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments | 2,600 |  |  |  |  |  |
Retained Earnings | Accounting Standards Update 2016-01 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Unrealized gain (loss) on equity method investments | $ 2,600 |  |  |  |  |  |
Royalty Agreements | Aziyo |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Effective interest rate for forecasted cash flows (as a percent) |  |  |  | 26.00% |  |  |
Royalty [Member] |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 36,127 | 21,931 | $ 88,343 | 60,372 |  |
Royalty [Member] | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 31,600 | 21,900 |  | 60,400 |  |
Promacta |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 27,800 |  | 68,200 |  |  |
Promacta | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 24,800 | 15,600 |  | 41,900 |  |
Kyprolis |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 6,300 |  | 14,400 |  |  |
Kyprolis | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 5,200 | 4,000 |  | 11,600 |  |
Evomela |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 1,300 |  | 4,100 |  |  |
Evomela | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 1,100 | 1,900 |  | 5,100 |  |
Other |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | 700 |  | $ 1,600 |  |  |
Other | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |
Total revenue |  | $ 500 | $ 400 |  | $ 1,800 |  |

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