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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2018
Equity [Abstract] |
Schedule of Accounting for Share-Based Compensation | The following table summarizes share-based compensation expense (in thousands):
| December 31, |  |  |  |
| 2018 |  | 2017 |  | 2016
Share-based compensation expense as a component of: |  |  |  |  |
Research and development expenses | $ | 8,352 |  | $ | 14,235 |  | $ | 8,836
General and administrative expenses | 12,494 |  | 10,680 |  | 10,057
| $ | 20,846 |  | $ | 24,915 |  | $ | 18,893
Schedule of Stock Option Plan Activity | Following is a summary of our stock option plan activity and related information:
| Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term in Years |  | Aggregate Intrinsic Value (In thousands)
Balance at December 31, 2017 | 1,876,332 |  | $ | 53.17 |  | 5.77 |  | $ | 157,340
Granted | 228,362 |  | 162.00 |  |  |  |
Exercised | (358,162) |  | 55.24 |  |  |  |
Forfeited | (10,228) |  | 114.53 |  |  |  |
Balance at December 31, 2018 | 1,736,304 |  | 66.71 |  | 5.47 |  | 125,858
Exercisable at December 31, 2018 | 1,313,374 |  | 47.03 |  | 4.56 |  | 117,314
Options vested and expected to vest as of December 31, 2018 | 1,734,304 |  | $ | 66.71 |  | 5.47 |  | $ | 125,858
Schedule of Stock Option Plan Activity by Exercise Price Range | Following is a further breakdown of the options outstanding as of December 31, 2018:
Range of exercise prices | Options outstanding |  | Weighted average remaining life in years |  | Weighted average exercise price |  | Options exercisable |  | Weighted average exercise price
$8.58 - $10.05 | 184,702 |  | 1.87 |  | $ | 10.00 |  | 184,702 |  | $ | 10.00
$10.12 - $12.81 | 46,510 |  | 2.92 |  | 11.40 |  | 46,510 |  | 11.40
$14.47 - $14.47 | 217,616 |  | 3.11 |  | 14.47 |  | 203,616 |  | 14.47
$16.14 - $17.88 | 38,790 |  | 0.17 |  | 16.36 |  | 38,790 |  | 16.36
$21.92 - $21.92 | 200,372 |  | 4.13 |  | 21.92 |  | 200,372 |  | 21.92
$32.00 - $56.26 | 182,767 |  | 5.70 |  | 50.38 |  | 174,470 |  | 50.10
$63.58 - $67.53 | 20,434 |  | 5.44 |  | 67.42 |  | 20,153 |  | 67.47
$74.42 - $74.42 | 190,825 |  | 5.12 |  | 74.42 |  | 190,825 |  | 74.42
$85.79 - $100.38 | 299,282 |  | 7.57 |  | 93.32 |  | 157,872 |  | 91.62
$101.15 - $195.91 | 353,006 |  | 8.79 |  | 148.50 |  | 96,064 |  | 131.77
| 1,734,304 |  | 5.47 |  | $ | 66.71 |  | 1,313,374 |  | $ | 47.03
Schedule of Stock Option Weighted-Average Assumptions | The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:
| Year Ended December 31, |  |  |  |  |
| 2018 |  | 2017 |  | 2016 |
Risk-free interest rate | 2.7%-3.0% |  | 2.0%-2.2% |  | 1.3%-1.9% |
Expected volatility | 33%-36% |  | 43%-47% |  | 48%-50% |
Expected term | 5.1 to 5.8 years |  | 6.5 to 6.8 years |  | 6.6 to 6.7 years |
Schedule of Restricted Stock Activity | The following is a summary of our restricted stock activity and related information:
| Shares |  | Weighted-Average Grant Date Fair Value
Outstanding at December 31, 2017 | 133,294 |  | $ | 91.60
Granted | 62,133 |  | 169.92
Vested | (61,989) |  | 86.19
Forfeited | (1,165) |  | 125.16
Outstanding at December 31, 2018 | 132,273 |  | $ | 130.63

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