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Investment in Viking - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 23, 2018 | Apr. 13, 2016 | May 31, 2014 | Mar. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Jul. 15, 2017 | Apr. 30, 2016 | Jan. 31, 2016 | Aug. 31, 2014
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Proceeds received from repayment of Viking note receivable |  |  |  |  | $ 3,914 | $ 200 | $ 300 |  |  |  |
Value of consideration received for repayment of convertible notes | $ 3,900 |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (USD per share) |  |  |  |  |  |  |  |  |  |  | $ 125.08
Warrants |  |  |  |  | 9,300 | $ 3,900 |  |  |  |  |
Debt | Viking |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Convertible loan facility extended |  |  | $ 2,500 |  |  |  |  |  |  |  |
Equity Method Investee |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Aggregate ownership (as a percent) |  |  |  |  |  | 17.60% | 30.30% |  |  |  |
Increase (decrease) in equity method investment |  |  |  |  |  | $ 2,700 | $ (10,700) |  |  |  |
Loss recorded (as a percent) |  |  |  | 12.40% |  |  |  |  |  |  |
Amount of loan to be repaid upon consummation of first capital financing transaction |  |  |  |  |  |  |  |  |  | $ 1,500 |
Proceeds received from repayment of Viking note receivable |  | $ 300 |  |  |  |  |  |  |  |  |
Shares received pursuant to MLA amendment (shares) |  | 960,000 |  |  |  |  |  |  |  |  |
Amount of loan to be repaid in cash upon consummation of first capital financing transaction |  |  |  |  |  |  |  | $ 200 |  |  |
Exercise price of warrants (USD per share) |  |  |  |  |  |  |  |  | $ 1.50 |  |
Other than temporary impairment of investment in Viking |  |  |  |  |  |  | 7,400 |  |  |  |
Warrants |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Gain on changes in fair value |  |  |  |  | $ 5,400 | $ 3,200 | $ 300 |  |  |  |
Viking Therapeutics, Inc. |  |  |  |  |  |  |  |  |  |  |
Variable Interest Entity [Line Items] |  |  |  |  |  |  |  |  |  |  |
Ownership interest (as a percent) |  |  |  |  | 8.80% |  |  |  |  |  |

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