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Business Combinations - Narrative (Details) |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Oct. 06, 2017 USD ($) numberOfCollaborationAgreements | Jan. 08, 2016 USD ($) | Oct. 31, 2018 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Business Acquisition [Line Items] |  |  |  |  |
Revenue royalty payable on all Cydex-related revenue (as a percent) |  |  |  |  | 20.00%
Cydex-related revenue amount that triggers royalty payments |  |  |  |  | $ 15,000,000.0
Finite-lived intangible asset, useful life |  |  |  | 20 years |
Goodwill |  |  |  | $ 86,646,000 | $ 85,959,000
Vernalis |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Gross payments to acquire business |  |  | $ 43,000,000.0 |  |
Projected cash flow discount rate (as a percent) |  |  | 34.00% |  |
Goodwill |  |  | $ 3,740,000 |  |
Crystal |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Gross payments to acquire business | $ 27,200,000 |  |  |  |
Working capital adjustment | 2,200,000 |  |  |  |
Total share consideration | 10,500,000 |  |  |  |
Cash payable to Crystal Shareholders | 336,000 |  |  | $ 200,000 |
Fair value of contingent consideration | 8,401,000 |  |  |  |
Goodwill | $ 10,697,000 |  |  |  |
OMT |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Gross payments to acquire business |  | $ 96,006,000 |  |  |
Total share consideration |  | 77,373,000 |  |  |
Goodwill |  | 59,969,000 |  |  |
Consideration transferred |  | $ 173,400,000 |  |  |
Core Technology | Vernalis |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Finite-lived intangible asset, useful life |  |  | 9 years |  |
Core Technology | Crystal |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Projected cash flow discount rate (as a percent) | 10.80% |  |  |  |
Average cash flow discount rate (as a percent) | 4.60% |  |  |  |
Finite-lived intangible asset, useful life | 20 years |  |  |  |
Core Technology | OMT |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Projected cash flow discount rate (as a percent) |  | 15.50% |  |  |
Finite-lived intangible asset, useful life |  | 20 years |  |  |
Threshold of Revenues above $15 million with Three Collaboration Agreements | Crystal |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Revenue royalty payable on all Cydex-related revenue (as a percent) | 10.00% |  |  |  |
Cydex-related revenue amount that triggers royalty payments | $ 15,000,000 |  |  |  |
Threshold of Revenues above $1.5 million with Four Collaboration Agreements | Crystal |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Revenue royalty payable on all Cydex-related revenue (as a percent) | 20.00% |  |  |  |
Cydex-related revenue amount that triggers royalty payments | $ 1,500,000 |  |  |  |
Number of collaboration agreements | numberOfCollaborationAgreements | 4 |  |  |  |

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