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Stockholders' Equity - Share-Based Compensation (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | $ 20,846 | $ 24,915 | $ 18,893
Research and development expenses |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | 8,352 | 14,235 | 8,836
General and administrative expenses |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |
Share-based compensation expense | $ 12,494 | $ 10,680 | $ 10,057

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- Definition The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References No definition available. + Details
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