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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating activities |  |  |
Net income (loss) | $ 143,321 | $ 12,556 | $ (1,636)
Less: gain from discontinued operations | 0 | 0 | 731
Income (loss) from continuing operations | 143,321 | 12,556 | (2,367)
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Change in estimated fair value of contingent liabilities | 3,448 | 2,580 | 3,334
Realized gain on sale of short-term investment | (2,611) | (831) | (2,352)
Depreciation and amortization | 14,718 | 11,714 | 11,290
Loss on equity investment in Viking | (42,346) | 2,048 | 23,132
Change in fair value of the convertible debt receivable from Viking and warrants | (5,411) | (4,032) | (462)
Amortization of premium (discount) on investments, net | (5,452) | (81) | 348
Amortization of debt discount and issuance fees | 43,954 | 11,619 | 10,925
Stock-based compensation | 20,846 | 24,915 | 18,893
Deferred income taxes | 29,739 | 44,518 | 10,697
Royalties recorded in retained earnings upon adoption of ASC 606 | 32,707 | 0 | 0
Change in derivative asset and liability fair value | 2,931 | 0 | 0
Changes in operating assets and liabilities, net of acquisition: |  |  |
Accounts receivable, net | (29,544) | (8,358) | (8,525)
Inventory | (2,559) | (843) | (244)
Other current assets | (868) | 402 | 526
Other long term assets | 728 | 0 | 183
Accounts payable and accrued liabilities | (4,542) | (1,713) | (2,369)
Contingent liabilities | (3,842) | (4,998) | (2,268)
Deferred revenue | (1,158) | (926) | (8)
Net cash provided by operating activities | 194,059 | 88,570 | 60,733
Investing activities |  |  |
Purchase of commercial license rights | (10,000) | 0 | (17,695)
Cash paid for acquisition, net of cash acquired | (5,856) | (26,653) | (92,502)
Payments to CVR holders and other contingency payments | (1,000) | 0 | 0
Purchases of property and equipment | (887) | (2,156) | (1,850)
Purchases of short-term investments | (1,434,255) | (254,258) | (164,438)
Proceeds from sale of short-term investments | 131,942 | 86,985 | 24,596
Proceeds from maturity of short-term investments | 892,873 | 109,649 | 118,874
Proceeds from commercial license rights | 0 | 7,054 | 0
Proceeds received from repayment of Viking note receivable | 3,914 | 200 | 300
Net cash used in investing activities | (423,269) | (79,179) | (134,415)
Financing activities |  |  |
Repayments of debt | (217,674) | 0 | 0
Gross proceeds from issuance of 2023 Convertible Senior Notes | 750,000 | 0 | 0
Payment of debt issuance costs | (16,900) | 0 | 0
Proceeds from issuance of warrants | 90,000 | 0 | 0
Purchase of convertible bond hedge | (140,250) | 0 | 0
Proceeds from bond hedge | 439,559 | 0 | 0
Payments to convert holders for bond conversion | (439,581) | 0 | 0
Net proceeds from stock option exercises and ESPP | 20,183 | 4,517 | 6,415
Taxes paid related to net share settlement of equity awards | (3,765) | (10,074) | (999)
Share repurchases | (122,868) | (1,966) | (3,901)
Repurchase of warrants | (30,094) | 0 | 0
Payments to CVR holders | (25) | 0 | (6,509)
Net cash (used in) provided by financing activities | 328,585 | (7,523) | (4,994)
Effect of exchange rate changes on cash | (215) | 0 | 0
Net increase (decrease) in cash and cash equivalents | 99,375 | 1,868 | (78,676)
Cash, cash equivalents, and restricted cash at end of year | 119,780 | 20,620 | 18,752
Cash, cash equivalents, and restricted cash at beginning of year | 20,620 | 18,752 | 97,428
Supplemental disclosure of cash flow information |  |  |
Interest paid | 1,513 | 1,838 | 1,838
Taxes paid | 341 | 157 | 38
Supplemental schedule of non-cash investing and financing activities |  |  |
Stock issued for acquisition, net of issuance cost | 0 | 0 | (77,331)
Stock and warrant received for repayment of Viking notes receivable | 0 | 0 | 1,200
Accrued inventory purchases | 2,059 | 1,007 | 646
Unrealized gain on AFS investments | 48 | 144 | (1,109)
Viking Therapeutics, Inc. |  |  |
Investing activities |  |  |
Common stock and warrants in equity method investments | 0 | 0 | (700)
Purchase of Common Stock |  |  |
Investing activities |  |  |
Common stock and warrants in equity method investments | $ 0 | $ 0 | $ (1,000)

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- Definition Amount of cash inflow (outflow) from investing activities, including discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3521-108585 + Details
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- Definition The cash outflow for a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 27 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3581-108585 + Details
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