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Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) | 3 Months Ended | 12 Months Ended |  |  |  |  |
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Dec. 31, 2018 USD ($) $ / shares | Sep. 30, 2018 USD ($) $ / shares | Jun. 30, 2018 USD ($) $ / shares | Mar. 31, 2018 USD ($) $ / shares | Dec. 31, 2017 USD ($) $ / shares | Sep. 30, 2017 USD ($) $ / shares | Jun. 30, 2017 USD ($) $ / shares | Mar. 31, 2017 USD ($) $ / shares | Dec. 31, 2018 USD ($) trading_day $ / shares | Dec. 31, 2017 USD ($) $ / shares | Dec. 31, 2016 USD ($) $ / shares | Dec. 31, 2007 $ / shares | Jan. 01, 2018 USD ($) | Oct. 06, 2017 USD ($) | Jan. 01, 2017 USD ($) | May 03, 2016 | Jan. 31, 2010 right
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain on AFS investments |  |  |  |  |  |  |  |  | $ 48,000 |  | $ 144,000 |  | $ (1,109,000) |  |  |  |  |  |  |
Maturity period of cash and cash equivalents, maximum |  |  |  |  |  |  |  |  | 3 months |  |  |  |  |  |  |  |  |  |  |
Write-downs related to obsolete inventory |  |  |  |  |  |  |  |  | $ 0 |  | 0 |  |  |  |  |  |  |  |  |
Retained earnings (accumulated deficit) | $ (229,197,000) |  |  |  | $ (400,924,000) |  |  |  | (229,197,000) |  | (400,924,000) |  |  |  |  |  |  |  |  |
Milestone payment received |  |  |  |  |  |  |  |  | 4,600,000 |  |  |  |  |  |  |  |  |  |  |
Third-party portion of milestone payment received |  |  |  |  |  |  |  |  | 3,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  | 1,600,000 |  |  |  |  |  |  |  |  |  |  |
Total revenues | 50,465,000 | $ 33,375,000 | $ 27,995,000 | $ 29,267,000 | 59,590,000 | $ 45,663,000 | $ 90,043,000 | $ 56,157,000 | 251,453,000 |  | 141,102,000 |  | 108,973,000 |  |  |  |  |  |  |
Net income (loss) | $ (7,007,000) | $ 8,426,000 | $ 6,058,000 | $ 5,079,000 | $ (42,482,000) | $ 67,362,000 | $ 73,160,000 | $ 45,279,000 | $ 143,321,000 |  | $ 12,556,000 |  | $ (1,636,000) |  |  |  |  |  |  |
Earnings per share - diluted (USD per share) | $ / shares | $ (0.33) | $ 0.36 | $ 0.26 | $ 0.22 | $ (2.02) | $ 2.80 | $ 2.99 | $ 1.83 | $ 5.96 | [1] | $ 0.53 | [1] | $ (0.08) | [1] |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Dividend declared (USD per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.50 |  |  |  |  |
Gain on disposition of product line |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,100,000 |  |  |  |  |  |  |
Provision for taxes on gain from discontinued operations |  |  |  |  |  |  |  |  | $ 0 |  | $ 0 |  | 408,000 |  |  |  |  |  |  |
Equity component of currently redeemable convertible notes (Note 6) | $ 0 |  |  |  | $ 18,859,000 |  |  |  | 0 |  | 18,859,000 |  |  |  |  |  |  |  |  |
Net cash used in investing activities |  |  |  |  |  |  |  |  | (423,269,000) |  | (79,179,000) |  | (134,415,000) |  |  |  |  |  |  |
Net cash provided by operating activities |  |  |  |  |  |  |  |  | 194,059,000 |  | 88,570,000 |  | 60,733,000 |  |  |  |  |  |  |
Net cash provided by financing activities |  |  |  |  |  |  |  |  | $ 328,585,000 |  | (7,523,000) |  | (4,994,000) |  |  |  |  |  |  |
Stock Options | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award expiration period |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Stock Options | Vest 1/8 on the six month anniversary of the date of grant | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  | 6 months |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  | 12.50% |  |  |  |  |  |  |  |  |  |  |
Stock Options | Vest 1/48 each month for forty-two months | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  | 42 months |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  | 2.08% |  |  |  |  |  |  |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Crystal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of share consideration |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,500,000 |  |  |
Metabasis Therapeutics |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of contingent value rights | right |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4
Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20.00% |
Palvella | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones | $ 8,000,000.0 |  |  |  |  |  |  |  | $ 8,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 9.80% |  |  |  |  |  |  |  | 9.80% |  |  |  |  |  |  |  |  |  |  |
Aziyo | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from royalties received |  |  |  |  |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones | $ 10,000,000.0 |  |  |  |  |  |  |  | $ 10,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Effective interest rate of forecasted cash flows (as a percent) |  |  |  |  |  |  |  |  | 26.00% |  |  |  |  |  |  |  |  |  |  |
CorMatrix | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |
Expiration period of royalty agreement |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
2023 Convertible Senior Notes | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount outstanding | $ 750,000,000.0 |  |  |  |  |  |  |  | $ 750,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Interest on debt instrument (as a percent) | 0.75% |  |  |  |  |  |  |  | 0.75% |  |  |  |  |  |  |  |  |  |  |
2019 Convertible Senior Notes | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Threshold business days for repayment of principal |  |  |  |  |  |  |  |  | 3 days |  |  |  |  |  |  |  |  |  |  |
Number of consecutive trading days | trading_day |  |  |  |  |  |  |  |  | 50 |  |  |  |  |  |  |  |  |  |  |
Accounting Standards Update 2016-09 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 18,103,000 |  |
Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 25,581,000 |  |  |  |
Accounting Standards Update 2016-01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Accounting Standards Update 2016-15 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net cash used in investing activities |  |  |  |  |  |  |  |  |  |  | (5,000,000.0) |  | (8,800,000) |  |  |  |  |  |  |
Net cash provided by operating activities |  |  |  |  |  |  |  |  |  |  | 5,000,000 |  | 2,300,000 |  |  |  |  |  |  |
Net cash provided by financing activities |  |  |  |  |  |  |  |  |  |  |  |  | 6,500,000 |  |  |  |  |  |  |
AOCI Including Portion Attributable to Noncontrolling Interest | Accounting Standards Update 2016-01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,700,000) |  |  |  |
Retained Earnings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net income (loss) |  |  |  |  |  |  |  |  | $ 143,321,000 |  | 12,556,000 |  | (1,636,000) |  |  |  |  |  |  |
Retained Earnings | Accounting Standards Update 2016-09 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,647,000 |  |
Retained Earnings | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,581,000 |  |  |  |
Retained Earnings | Accounting Standards Update 2016-01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,662,000 |  |  |  |
Difference between Revenue Guidance in Effect before and after Topic 606 | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Retained earnings (accumulated deficit) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (25,600,000) |  |  |  |
Dividend yield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Measurement input | 0 |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |
Palvella | Director |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ownership in entity by director (as a percent) |  |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |  |
Royalties |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ 128,556,000 |  | 88,685,000 |  | 59,423,000 |  |  |  |  |  |  |
Royalties | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 121,000,000.0 |  | 88,700,000 |  | 59,400,000 |  |  |  |  |  |  |
Royalty, Promacta |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 99,300,000 |  |  |  |  |  |  |  |  |  |  |
Royalty, Promacta | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 92,300,000 |  | 62,900,000 |  | 43,000,000.0 |  |  |  |  |  |  |
Royalty, Kyprolis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 21,700,000 |  |  |  |  |  |  |  |  |  |  |
Royalty, Kyprolis | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 20,900,000 |  | 16,400,000 |  | 12,100,000 |  |  |  |  |  |  |
Royalty, Evomela |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 5,700,000 |  |  |  |  |  |  |  |  |  |  |
Royalty, Evomela | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 5,700,000 |  | 7,200,000 |  | 1,400,000 |  |  |  |  |  |  |
Royalty, Other |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 1,900,000 |  |  |  |  |  |  |  |  |  |  |
Royalty, Other | Calculated under Revenue Guidance in Effect before Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ 2,100,000 |  | $ 2,200,000 |  | $ 2,900,000 |  |  |  |  |  |  |
[1] | The sum of net income per share amounts may not equal the total due to rounding

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