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Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Notes receivable fair market value adjustment | $ 0 |  |
Increase (decrease) in notes receivable fair value |  | $ (900) | $ (200)
Recurring |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 656,665 | 188,764 |
Liabilities, fair value | 12,741 | 14,245 |
Recurring | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 6,477 | 8,401 |
Recurring | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 514 | 1,589 |
Recurring | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 5,551 | 3,971 |
Recurring | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 199 | 284 |
Recurring | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 647,408 | 181,041 |
Recurring | Notes receivable Viking |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 3,877 |
Recurring | Investment in warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 9,257 | 3,846 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 56,774 | 5,742 |
Liabilities, fair value | 199 | 284 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 199 | 284 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 47,517 | 1,896 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Notes receivable Viking |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 9,257 | 3,846 |
Recurring | Significant Other Observable Inputs (Level 2) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 599,891 | 179,145 |
Liabilities, fair value | 5,551 | 3,971 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 5,551 | 3,971 |
Recurring | Significant Other Observable Inputs (Level 2) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 599,891 | 179,145 |
Recurring | Significant Other Observable Inputs (Level 2) | Notes receivable Viking |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Investment in warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 0 | 3,877 |
Liabilities, fair value | 6,991 | 9,990 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 6,477 | 8,401 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 514 | 1,589 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Notes receivable Viking |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 3,877 |
Recurring | Significant Unobservable Inputs (Level 3) | Investment in warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 0 | $ 0 |
Volatility | Recurring | Notes receivable Viking |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Measurement input |  | 0.75 |
Transferred over Time | Phase 3 Clinical Trial |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Gross contract asset | 10,000 |  |
Maximum | Transferred over Time | Development, Regulatory, & Commercial Milestones and Tiered Royalties |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Gross contract asset | 375,000 |  |
Maximum | Transferred over Time | Milestone Payments and Royalties |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Gross contract asset | $ 529,000 |  |

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