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Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018
Contingent liabilities - Crystal |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Payment for contingent consideration liabilities | $ 3,000 | $ 1,800
Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 998,324 | 656,665
Liabilities, fair value | 9,017 | 12,741
Recurring | Contingent liabilities - Crystal |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 2,659 | 6,477
Recurring | Contingent liabilities - CyDex |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 348 | 514
Recurring | Contingent liabilities - Metabasis |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 5,935 | 5,551
Recurring | Liability for restricted investments owed to former licensees |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 75 | 199
Recurring | Short-term investments |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 939,989 | 601,217
Recurring | Investment in Viking common stock |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 48,425 | 46,191
Recurring | Investment in warrants |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 9,910 | 9,257
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 61,408 | 56,774
Liabilities, fair value | 75 | 199
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Crystal |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - CyDex |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Metabasis |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for restricted investments owed to former licensees |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 75 | 199
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 3,073 | 1,326
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in Viking common stock |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 48,425 | 46,191
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in warrants |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 9,910 | 9,257
Recurring | Significant Other Observable Inputs (Level 2) |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 936,791 | 599,891
Liabilities, fair value | 5,935 | 5,551
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Crystal |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - CyDex |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Metabasis |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 5,935 | 5,551
Recurring | Significant Other Observable Inputs (Level 2) | Liability for restricted investments owed to former licensees |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 936,791 | 599,891
Recurring | Significant Other Observable Inputs (Level 2) | Investment in Viking common stock |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 0 | 0
Recurring | Significant Other Observable Inputs (Level 2) | Investment in warrants |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 0 | 0
Recurring | Significant Unobservable Inputs (Level 3) |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 125 | 0
Liabilities, fair value | 3,007 | 6,991
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Crystal |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 2,659 | 6,477
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - CyDex |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 348 | 514
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Metabasis |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Significant Unobservable Inputs (Level 3) | Liability for restricted investments owed to former licensees |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Liabilities, fair value | 0 | 0
Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 125 | 0
Recurring | Significant Unobservable Inputs (Level 3) | Investment in Viking common stock |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 0 | 0
Recurring | Significant Unobservable Inputs (Level 3) | Investment in warrants |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Assets, fair value | 0 | $ 0
Transferred over Time | Phase 3 Clinical Trial |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Gross contract asset | 10,000 |
Maximum | Transferred over Time | Development, Regulatory, & Commercial Milestones and Tiered Royalties |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Gross contract asset | $ 375,000 |

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