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Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract] |  |  |  |  |  |  |  |  |  |  |
Tax at federal statutory rate |  |  |  |  |  |  |  |  | $ (2,213) | $ 167,294 | $ 36,400
State, net of federal benefit |  |  |  |  |  |  |  |  | (1,456) | 2,466 | 1,635
Contingent liabilities |  |  |  |  |  |  |  |  | (278) | 18 | 948
Share-based compensation |  |  |  |  |  |  |  |  | (362) | (819) | (8,131)
FDII |  |  |  |  |  |  |  |  | (1,652) | (402) | 0
Research and development credits |  |  |  |  |  |  |  |  | (699) | (879) | (2,758)
Change in uncertain tax positions |  |  |  |  |  |  |  |  | (650) | 441 | 858
Rate change for changes in federal or state law |  |  |  |  |  |  |  |  | (173) | (210) | 178
Provision to return adjustments |  |  |  |  |  |  |  |  | (4,803) | (184) | (150)
Foreign tax differential on income/loss of foreign subsidiaries |  |  |  |  |  |  |  |  | (3,839) | 57 | (14)
Change in valuation allowance |  |  |  |  |  |  |  |  | (121,876) | (1,193) | (4,225)
Sale of Vernalis R&D |  |  |  |  |  |  |  |  | 127,372 | 0 | 0
Expired NOLs and credits |  |  |  |  |  |  |  |  | 0 | 0 | 3,054
Change in derivatives |  |  |  |  |  |  |  |  | 0 | 0 | 615
Other |  |  |  |  |  |  |  |  | 3,076 | 748 | 1,599
Income tax expense from continuing operations | $ (2,391) | $ (4,911) | $ 6,033 | $ (6,284) | $ (810) | $ (4,620) | $ (3,609) | $ 176,376 | $ (7,553) | $ 167,337 | $ 30,009

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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