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Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2020

Equity [Abstract]

Schedule of Share-Based Compensation Expense

The following table summarizes non-cash share-based compensation expense (in thousands):

			December 31,
			2020						2019						2018
Share-based compensation expense as a component of:
Research and development expenses			$	13,497					$	9,641					$	8,352
General and administrative expenses			17,230						14,874						12,494
			$	30,727					$	24,515					$	20,846

Schedule of Stock Option Plan Activity

Following is a summary of our stock option plan activity and related information:

			Shares						Weighted Average Exercise Price						Weighted Average Remaining Contractual Term in Years						Aggregate Intrinsic Value (In  thousands)
Balance at January 1, 2018			1,876,332						$	53.17					5.77						$	157,340
Granted			228,362						$	162.00
Exercised			(358,162)						$	55.24
Forfeited			(10,228)						$	114.53
Balance at December 31, 2018			1,736,304						$	66.71					5.47						125,858
Exercisable at December 31, 2018			1,313,374						$	47.03					4.56						117,314
Options vested and expected to vest as of December 31, 2018			1,736,304						$	66.71					5.47						$	125,858
Granted			338,617						$	116.69
Exercised			(112,011)						$	23.65
Forfeited			(6,531)						$	139.37
Balance at December 31, 2019			1,956,379						$	77.54					5.45						72,002
Exercisable at December 31, 2019			1,454,726						$	61.82					4.42						70,345
Options vested and expected to vest as of December 31, 2019			1,956,379						$	77.54					5.45						$	72,002
Granted			806,300						$	92.93
Exercised			(156,845)						$	21.26
Forfeited			(44,012)						$	91.30
Balance at December 31, 2020			2,561,822						$	85.59					6.09						59,033
Exercisable at December 31, 2020			1,611,830						$	76.05					4.54						53,286
Options vested and expected to vest as of December 31, 2020			2,561,822						$	85.59					6.09						$	59,033

Schedule of Stock Option Plan Activity by Exercise Price Range

Following is a further breakdown of the options outstanding as of December 31, 2020:

Range of exercise prices			Options outstanding						Weighted average remaining  life in years						Weighted average exercise price						Options exercisable						Weighted average exercise price
$10.05-$14.47			284,184						0.86						$	13.08					270,184						$	13.00
$21.92-$56.26			344,629						2.88						$	35.34					344,629						$	35.34
$63.58-$74.42			307,356						5.20						$	71.96					220,650						$	73.41
$82.90-$95.35			185,033						6.23						$	86.22					140,400						$	86.32
$95.68			305,106						9.12						$	95.68					63,059						$	95.68
$97.92			4,976						5.02						$	97.92					4,976						$	97.92
$98.20			270,850						9.26						$	98.20					—						$	98.20
$100.02-$113.76			257,914						6.69						$	104.12					220,092						$	103.96
$117.58			19,744						9.44						$	117.58					—						$	117.58
$117.97-$195.91			582,030						7.56						$	137.18					347,840						$	141.38
			2,561,822						6.09						$	85.59					1,611,830						$	76.05

Schedule of Stock Option Weighted-Average Assumptions

The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:

			Year Ended December 31,
			2020						2019						2018
Risk-free interest rate			0.2%-1.4%						1.4%-2.6%						2.7%-3.0%
Expected volatility			47%-71%						40%-49%						33%-36%
Expected term			4.7 to 5.1 years						4.6 to 5.9 years						5.1 to 5.8 years

Schedule of Restricted Stock Activity

The following is a summary of our restricted stock activity and related information: 

			Shares						Weighted-Average Grant Date Fair Value
												Outstanding at January 1, 2018			133,294						$	91.60
Granted			62,133						$	169.92
Vested			(61,989)						$	86.19
Forfeited			(1,165)						$	125.16
Outstanding at December 31, 2018			132,273						$	130.63
Granted			118,498						$	115.90
Vested			(102,846)						$	121.55
Forfeited			(666)						$	134.36
Outstanding at December 31, 2019			147,259						$	125.11
Granted			111,306						$	89.73
Vested			(52,363)						$	121.69
Forfeited			—						$	—
Outstanding at December 31, 2020			206,202						$	106.88

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