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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net income (loss) | $ 57,138 | $ (2,985) | $ 629,302
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |  |
Gain from sale of Promacta license | 0 | 0 | (812,797)
Gain from sale of Vernalis R&D | 0 | (17,114) | 0
Change in estimated fair value of contingent liabilities | (36,962) | 963 | (30)
Depreciation of fixed assets and amortization of intangible assets | 51,071 | 25,691 | 18,361
Loss (gain) short-term investments | 3,997 | 16,933 | (1,049)
Amortization/accretion of premium (discount) on investments, net | 111 | 1,479 | (10,274)
Amortization of debt discount and issuance fees | 16,692 | 23,077 | 29,988
Loss on debt extinguishment | 7,303 | 2,466 | 0
Amortization of commercial license and other economic rights | (125) | 2,275 | 25,370
Share-based compensation | 38,783 | 30,727 | 24,515
Deferred income taxes, net | (8,618) | (19,053) | 74,829
Other | 1,572 | 191 | (3,498)
Changes in operating assets and liabilities, net of acquisitions: |  |  |
Accounts receivable, net | (28,616) | (26,061) | 25,463
Inventory | (427) | (17,799) | (2,061)
Accounts payable and accrued liabilities | 2,810 | (1,245) | (6,664)
Income taxes receivable | (3,976) | 9,144 | (11,219)
Other economic rights | 0 | 0 | (12,000)
Deferred revenue | (17,870) | 29,236 | (1,147)
Other | (4,085) | (3,339) | 3,575
Net cash provided by (used in) operating activities | 78,798 | 54,586 | (29,336)
Investing activities |  |  |
Proceeds from sale of Promacta license | 0 | 0 | 812,797
Cash paid for acquisition, net of cash and restricted cash acquired | 0 | (404,884) | (11,840)
Purchases of property and equipment | (8,761) | (4,458) | (2,553)
Purchases of short-term investments | (181,325) | (422,523) | (2,356,545)
Proceeds from commercial license rights | 494 | 1,358 | 0
Proceeds from sale of short-term investments | 154,230 | 394,539 | 535,877
Proceeds from maturity of short-term investments | 67,105 | 644,155 | 1,494,851
Cash paid for equity method investment | 0 | (500) | (1,000)
Proceeds on sale of Vernalis R&D, net | 0 | 22,061 | 0
Other, net | (1,220) | 1,900 | (4,669)
Net cash provided by investing activities | 30,523 | 231,648 | 466,918
Financing activities |  |  |
Repayment of debt | (155,760) | (222,209) | (27,323)
Payments under finance lease obligations | (9,188) | (9,549) | 0
Proceeds from bond hedge settlement | 18,938 | 0 | 12,401
Payments to convert holders for bond conversion | 0 | 0 | (12,401)
Net proceeds from stock option exercises and ESPP | 33,763 | 3,017 | 2,997
Taxes paid related to net share settlement of equity awards | (6,018) | (1,481) | (4,418)
Share repurchases | 0 | (77,998) | (453,048)
Repurchase of warrants | (18,446) | 0 | (380)
Payments to CVR Holders | (1,050) | (2,325) | (3,000)
Net cash used in financing activities | (137,761) | (310,545) | (485,172)
Net decrease in cash, cash equivalents, and restricted cash | (28,440) | (24,311) | (47,590)
Effect of exchange rate changes on cash | 0 | 0 | 83
Cash, cash equivalents and restricted cash at beginning of year | 47,962 | 72,273 | 119,780
Cash, cash equivalents and restricted cash at end of year | 19,522 | 47,962 | 72,273
Cash paid during the year: |  |  |
Interest paid | 3,028 | 4,463 | 5,827
Taxes paid | 3,722 | 2,130 | 103,817
Restricted cash in other current assets | 0 | 343 | 730
Supplemental schedule of non-cash investing and financing activities |  |  |
Accrued inventory purchases | 1,974 | 1,562 | 170
Unrealized (loss) gain on available-for-sale investments | (221) | (212) | 256
Purchase of fixed assets recorded in accounts payable | $ 1,567 | $ 249 | $ 495

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