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Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 USD ($) agreement | Dec. 31, 2020 USD ($) | Jan. 31, 2010 agreement
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Number of CVR agreements | agreement | 4 |  | 4
Transferred over Time | Phase 3 Clinical Trial |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Gross contract asset | $ 10,000,000 |  |
Maximum | Transferred over Time | Development, Regulatory, & Commercial Milestones and Tiered Royalties |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Investments | 375,000,000 |  |
Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Payment for contingent consideration liabilities |  | $ 1,800,000 |
Contingent liabilities - Icagen |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Payment for contingent consideration liabilities | 1,100,000 |  |
Contingent liabilities - Pfenex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Reduction in contingent liability | 37,600,000 |  |
Recurring |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 321,586,000 | 363,567,000 |
Liabilities, fair value | 11,157,000 | 49,193,000 |
Recurring | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 800,000 |
Recurring | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 349,000 | 508,000 |
Recurring | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 3,358,000 | 3,821,000 |
Recurring | Contingent liabilities - Icagen |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 7,364,000 | 6,404,000 |
Recurring | Contingent liabilities - Pfenex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 37,600,000 |
Recurring | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 86,000 | 60,000 |
Recurring | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 290,697,000 | 324,478,000 |
Recurring | Investment in Viking common stock |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 30,889,000 | 32,763,000 |
Recurring | Investment in Viking warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 6,326,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 40,624,000 | 42,527,000 |
Liabilities, fair value | 86,000 | 60,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Icagen |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Pfenex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 0 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 86,000 | 60,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 9,735,000 | 3,438,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in Viking common stock |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 30,889,000 | 32,763,000 |
Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in Viking warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 6,326,000 |
Recurring | Significant Other Observable Inputs (Level 2) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 280,553,000 | 320,647,000 |
Liabilities, fair value | 3,358,000 | 3,821,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 3,358,000 | 3,821,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Icagen |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Pfenex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 280,553,000 | 320,647,000 |
Recurring | Significant Other Observable Inputs (Level 2) | Investment in Viking common stock |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 0 | 0 |
Recurring | Significant Other Observable Inputs (Level 2) | Investment in Viking warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | 0 |
Recurring | Significant Unobservable Inputs (Level 3) |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 409,000 | 393,000 |
Liabilities, fair value | 7,713,000 | 45,312,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Crystal |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 800,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - CyDex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 349,000 | 508,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Metabasis |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Icagen |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 7,364,000 | 6,404,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Pfenex |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value |  | 37,600,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Liability for restricted investments owed to former licensees |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Liabilities, fair value | 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | 409,000 | 393,000 |
Recurring | Significant Unobservable Inputs (Level 3) | Investment in Viking common stock |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value | $ 0 | 0 |
Recurring | Significant Unobservable Inputs (Level 3) | Investment in Viking warrants |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |
Assets, fair value |  | $ 0 |

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