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Balance Sheet Account Details - Narrative (Details) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 USD ($) position agreement | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Jan. 31, 2010 agreement
Schedule of Investments [Line Items] |  |  |  |
Number of positions in an unrealized loss position | position | 55 |  |  |
Depreciation expense | $ 3,900,000 | $ 1,800,000 | $ 1,500,000 |
Finite-lived intangible asset, useful life | 20 years |  |  |
Amortization expense | $ 47,200,000 | 23,400,000 | 16,900,000 |
Estimated amortization expense for 2022 | 47,000,000 |  |  |
Estimated amortization expense for 2023 | 47,000,000 |  |  |
Estimated amortization expense for 2024 | 47,000,000 |  |  |
Estimated amortization expense for 2025 | 47,000,000 |  |  |
Impairment of intangible assets with finite lives | $ 0 | $ 0 | $ 0 |
Number of CVR agreements | agreement | 4 |  |  | 4
Minimum |  |  |  |
Schedule of Investments [Line Items] |  |  |  |
Property and equipment, useful life | 3 years |  |  |
Maximum |  |  |  |
Schedule of Investments [Line Items] |  |  |  |
Property and equipment, useful life | 10 years |  |  |

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