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Basis of Presentation and Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
Schedule of Revenue from Significant Partners | Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:
| Year-ended December 31,
| 2021 |  | 2020 |  | 2019
Partner A | 41% |  | 45% |  | N/A
Partner B | 14% |  | 17% |  | 27%
Partner C | <10% |  | <10% |  | 13%
Schedule of Commercial License Rights | As of December 31, 2021 and 2020, commercial license and other economic rights consist of the following (in thousands):
|  | December 31, 2021 |  | December 31, 2020
|  | Gross |  | Adjustments(1) |  | Net |  | Gross |  | Adjustments(2) |  | Net
Aziyo and CorMatrix |  | $ | 17,696 |  |  | $ | (9,461) |  |  | $ | 8,235 |  |  | $ | 17,696 |  |  | $ | (9,588) |  |  | $ | 8,108 |
Selexis and Dianomi |  | 10,602 |  |  | (8,727) |  |  | 1,875 |  |  | 10,602 |  |  | (7,731) |  |  | 2,871 |
Total |  | $ | 28,298 |  |  | $ | (18,188) |  |  | $ | 10,110 |  |  | $ | 28,298 |  |  | $ | (17,319) |  |  | $ | 10,979 |
(1) Amounts represent accumulated amortization to principal of $11.7 million and credit loss adjustments of $6.5 million as of December 31, 2021. (2) Amounts represent accumulated amortization to principal of $11.3 million and credit loss adjustments of $6.0 million as of December 31, 2020.
Schedule of Disaggregation of Revenue | Royalty revenue for 2021, 2020 and 2019 are reported as below (in thousands):
|  | Year ended December 31,
|  | 2021 |  | 2020 |  | 2019
Kyprolis |  | $ | 27,472 |  |  | $ | 25,164 |  |  | $ | 25,046 |
Evomela |  | 10,079 |  |  | 6,377 |  |  | 5,171 |
Other |  | 11,376 |  |  | 2,255 |  |  | 2,566 |
Promacta |  | N/A |  | N/A |  | 14,193 |
|  | $ | 48,927 |  |  | $ | 33,796 |  |  | $ | 46,976 |
The following table represents disaggregation of Captisol and Contract Revenue (in thousands):
|  | Year ended December 31,
|  | 2021 |  | 2020 |  | 2019
Captisol |  | $ | 164,250 |  |  | $ | 109,959 |  |  | $ | 31,489 |
Contract |  |  |  |  |  |
Service Revenue |  | 23,712 |  |  | 21,803 |  |  | 16,776 |
License Fees |  | 5,084 |  |  | 4,378 |  |  | 6,199 |
Milestone |  | 28,748 |  |  | 11,516 |  |  | 17,173 |
Other |  | 6,412 |  |  | 4,967 |  |  | 1,669 |
|  | $ | 63,956 |  |  | $ | 42,664 |  |  | $ | 41,817 |
Schedule of Computation of Basic and Diluted Net Income (Loss) per Share | The following table presents the calculation of weighted average shares used to calculate basic and diluted income (loss) per share (in thousands):
| Year Ended December 31,
| 2021 |  | 2020 |  | 2019
Weighted average shares outstanding: | 16,630 |  |  | 16,185 |  |  | 18,995 |
Dilutive potential common shares: |  |  |  |  |
Restricted stock | 96 |  |  | — |  |  | 43 |
Stock options | 520 |  |  | — |  |  | 719 |
Shares used to compute diluted income (loss) per share | 17,246 |  |  | 16,185 |  |  | 19,757 |
Potentially dilutive shares excluded from calculation due to anti-dilutive effect | 4,793 |  |  | 8,458 |  |  | 8,926 |

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