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Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) $ / shares in Units, shares in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |
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May 31, 2017 USD ($) | May 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2021 USD ($) segment shares | Dec. 31, 2020 USD ($) shares | Dec. 31, 2019 USD ($) shares | Dec. 31, 2007 $ / shares | Oct. 01, 2020 USD ($) $ / shares | Apr. 01, 2020 USD ($) | Jan. 01, 2020 USD ($) | Aug. 15, 2019 USD ($) | May 31, 2018 USD ($) | May 22, 2018 USD ($) | Aug. 31, 2014 USD ($) | Jan. 31, 2010 right
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of business segments | segment |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |
Maturity period of cash and cash equivalents, maximum |  |  |  | 3 months |  |  |  |  |  |  |  |  |  |  |
Write-downs related to obsolete inventory |  |  |  | $ 0 | $ 0 | $ 0 |  |  |  |  |  |  |  |  |
Inventory |  |  |  | 27,326,000 | 26,487,000 |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | 277,133,000 | 186,419,000 | 120,282,000 |  |  |  |  |  |  |  |  |
Additional reserve for credit losses due to COVID-19 |  |  |  | $ (500,000) | (500,000) |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  | $ 30,100,000 | $ 900,000 |  |  |  |  |  |  |  |  |
Dividend declared (USD per share) | $ / shares |  |  |  |  |  |  | $ 2.50 |  |  |  |  |  |  |  |
Potentially dilutive shares excluded from calculation due to anti-dilutive effect (shares) | shares |  |  |  | 4,793 | 8,458 | 8,926 |  |  |  |  |  |  |  |  |
Equity Awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potentially dilutive shares excluded from calculation due to anti-dilutive effect (shares) | shares |  |  |  |  | 600 |  |  |  |  |  |  |  |  |  |
Contract revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 63,956,000 | $ 42,664,000 | $ 41,817,000 |  |  |  |  |  |  |  |  |
Captisol |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Inventory |  |  |  | 24,600,000 | 26,100,000 |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 164,250,000 | 109,959,000 | $ 31,489,000 |  |  |  |  |  |  |  |  |
Stock Options | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award expiration period |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Stock Options | Vest 1/8 on the six month anniversary of the date of grant | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  | 6 months |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  | 12.50% |  |  |  |  |  |  |  |  |  |  |
Stock Options | Vest 1/48 each month for forty-two months | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  | 42 months |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  | 2.08% |  |  |  |  |  |  |  |  |  |  |
RSUs and PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
Minimum | PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  | 0.00% |  |  |  |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Maximum | PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  | 200.00% |  |  |  |  |  |  |  |  |  |  |
Pfenex |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration liability per share (USD per share) | $ / shares |  |  |  |  |  |  |  | $ 2.00 |  |  |  |  |  |  |
Contingent consideration liability |  |  |  |  |  |  |  | $ 77,800,000 |  |  |  |  |  |  |
Icagen |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration liability |  |  |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |  |
Metabasis Therapeutics |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of contingent value rights | right |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4
Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 20.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets, net |  |  |  | $ 10,110,000 | 10,979,000 |  |  |  |  |  |  |  |  |  |
Credit loss adjustments on finite-lived intangible assets |  |  |  | $ 6,500,000 | 6,000,000 |  |  |  |  |  |  |  |  |  |
Licensing Agreements | Accounting Standards Update 2016-13 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Credit loss adjustments on finite-lived intangible assets |  |  |  |  |  |  |  |  |  | $ 5,500,000 |  |  |  |  |
Novan | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones |  | $ 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Royalty Agreements | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  | 10.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment for license |  | $ 12,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Contract revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 3,000,000 |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones |  |  | $ 8,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  |  | 9.80% |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment for license |  |  | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets, net |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Aziyo | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from royalties received | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate of forecasted cash flows (as a percent) |  |  |  | 21.60% |  |  |  |  |  |  |  |  |  |  |
Aziyo | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
CorMatrix | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period of royalty agreement | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
Selexis | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate of forecasted cash flows (as a percent) |  |  |  | 21.00% |  |  |  |  |  |  |  |  |  |  |
2023 Convertible Senior Notes | Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount of 2023 Notes outstanding |  |  |  |  |  |  |  |  |  |  |  | $ 750,000,000 |  |  |
Interest on debt instrument (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 0.75% |  |  |
2023 Convertible Senior Notes | Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount of 2023 Notes outstanding |  |  |  | $ 343,301,000 | $ 495,280,000 |  |  |  |  |  |  |  | $ 750,000,000 |  |
Interest on debt instrument (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 0.75% |  |
2019 Convertible Senior Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative asset |  |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |
Derivative liability |  |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |
2019 Convertible Senior Notes | Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount of 2023 Notes outstanding |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 245,000,000 |
Interest on debt instrument (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.75% |
Dividend yield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Measurement input (as a percent) |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |

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