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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues:      
Total revenues $ 277,133 $ 186,419 $ 120,282
Operating costs and expenses:      
Cost of Captisol 62,176 30,419 11,347
Amortization of intangibles 47,167 23,442 16,864
Research and development 69,012 59,392 55,908
General and administrative 57,483 64,435 41,884
Other operating income (37,600) 0 0
Total operating costs and expenses 198,238 177,688 126,003
Income from operations 78,895 25,845 807,076
Other income (expense):      
Gain (loss) from short-term investments (3,997) (16,933) 1,049
Interest income 886 8,078 28,430
Interest expense (19,626) (27,420) (35,745)
Other expense, net (8,860) (108) (4,171)
Total other expense, net (31,597) (36,383) (10,437)
Income (loss) before income tax 47,298 (10,538) 796,639
Income tax benefit (expense) 9,840 7,553 (167,337)
Net income (loss) $ 57,138 $ (2,985) $ 629,302
Earnings Per Share [Abstract]      
Basic net income (loss) per share (USD per share) $ 3.44 $ (0.18) $ 33.13
Shares used in basic per share calculation (shares) 16,630 16,185 18,995
Diluted net income (loss) per share (USD per share) $ 3.31 $ (0.18) $ 31.85
Shares used in diluted per share calculation (shares) 17,246 16,185 19,757
Royalties      
Revenues:      
Total revenues $ 48,927 $ 33,796 $ 46,976
Captisol      
Revenues:      
Total revenues 164,250 109,959 31,489
Contract revenue      
Revenues:      
Total revenues 63,956 42,664 41,817
Vernalis      
Operating costs and expenses:      
Gain from sale of intangible assets 0 17,114 0
Promacta      
Operating costs and expenses:      
Gain from sale of intangible assets $ 0 $ 0 $ 812,797