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Balance Sheet Account Details - Narrative (Details)
 12 Months Ended
Dec. 31, 2021
USD ($)
position
agreement
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Jan. 31, 2010
agreement
Schedule of Investments [Line Items]        
Number of positions in an unrealized loss position | position 55      
Depreciation expense $ 3,900,000 $ 1,800,000 $ 1,500,000  
Finite-lived intangible asset, useful life 20 years      
Amortization expense $ 47,200,000 23,400,000 16,900,000  
Estimated amortization expense for 2022 47,000,000      
Estimated amortization expense for 2023 47,000,000      
Estimated amortization expense for 2024 47,000,000      
Estimated amortization expense for 2025 47,000,000      
Impairment of intangible assets with finite lives $ 0 $ 0 $ 0  
Number of CVR agreements | agreement 4     4
Minimum        
Schedule of Investments [Line Items]        
Property and equipment, useful life 3 years      
Maximum        
Schedule of Investments [Line Items]        
Property and equipment, useful life 10 years