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Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]      
Tax at federal statutory rate $ 9,932 $ (2,213) $ 167,294
State, net of federal benefit (408) (1,456) 2,466
Contingent liabilities (8,161) (278) 18
Share-based compensation (11,919) (362) (819)
FDII (637) (1,652) (402)
Research and development credits (2,692) (699) (879)
Change in uncertain tax positions 586 (650) 441
Rate change for changes in federal, foreign or state law (7,963) (173) (210)
Provision to return adjustments (617) (4,803) (184)
Foreign tax differential on income/loss of foreign subsidiaries (114) (3,839) 57
Change in valuation allowance 11,410 (121,876) (1,193)
Sale of Vernalis R&D 0 127,372 0
Other 743 3,076 748
Total income tax expense (benefit) $ (9,840) $ (7,553) $ 167,337