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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 USD ($) | Jun. 30, 2021 USD ($)
Cash flows from operating activities: |  |
Net (loss) income | $ (16,280) | $ 48,831
Adjustments to reconcile net (loss) income to net cash provided by operating activities: |  |
Change in estimated fair value of contingent liabilities | (1,266) | (33,502)
Depreciation and amortization of intangible assets | 26,921 | 25,179
Amortization of premium on investments, net | 44 | 109
Amortization of debt discount and issuance fees | 501 | 9,073
Amortization of commercial license rights | (190) | 206
Loss (gain) on debt extinguishment | (3,326) | 7,175
Share-based compensation | 18,543 | 18,621
Deferred income taxes | (12,925) | (9,766)
Loss (gain) from short-term investments | 14,786 | (6,197)
Lease amortization expense | 3,054 | 2,113
Other | (67) | 595
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 23,208 | (2,659)
Inventory | 9,740 | (2,326)
Accounts payable and accrued liabilities | (4,357) | (4,340)
Income tax receivable and payable | 9,011 | (2,477)
Deferred revenue | (2,254) | (14,605)
Other assets and liabilities | (1,254) | (4,899)
Net cash provided by operating activities | 63,889 | 31,131
Cash flows from investing activities: |  |
Purchase of short-term investments | (38,472) | (96,136)
Proceeds from sale of short-term investments | 177,554 | 150,648
Proceeds from maturity of short-term investments | 24,830 | 34,600
Cash paid for equity method investment | (750) | 0
Purchase of property and equipment | (11,463) | (4,794)
Other | 33 | 135
Net cash provided by investing activities | 151,732 | 84,453
Cash flows from financing activities: |  |
Repurchase of 2023 Notes | (223,303) | (153,381)
Payments under financing lease obligations | (27) | (9,188)
Proceeds from convertible bond hedge settlement | 0 | 16,855
Payments to convertible bond holders for warrant purchases | 0 | (16,459)
Net proceeds from stock option exercises and ESPP | 1,011 | 27,584
Taxes paid related to net share settlement of equity awards | (5,922) | (5,901)
Payments to CVR Holders | (1,416) | (1,050)
Payments for OmniAb transaction costs | (206) | 0
Net cash used in financing activities | (229,863) | (141,540)
Net decrease in cash, cash equivalents and restricted cash | (14,242) | (25,956)
Cash, cash equivalents and restricted cash at beginning of period | 19,522 | 47,963
Cash, cash equivalents and restricted cash at end of period | 5,280 | 22,007
Supplemental disclosure of cash flow information: |  |
Interest paid | 1,038 | 1,737
Taxes paid | 20 | 3,552
Restricted cash in other current assets | 0 | 144
Supplemental schedule of non-cash activity: |  |
Accrued fixed asset purchases | 3,800 | 359
Accrued inventory purchases | 9,161 | 12,695
Unrealized loss on AFS investments | $ (149) | $ (60)

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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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