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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | $ 9,499 | $ 10,216 | $ 18,543 | $ 18,621
SBC - Research and development expenses |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | 4,501 | 4,556 | 8,415 | 8,495
SBC - General and administrative expenses |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | $ 4,998 | $ 5,660 | $ 10,128 | $ 10,126

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