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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Cash flows from operating activities: |  |
Net (loss) income | $ (15,876) | $ 62,554
Adjustments to reconcile net (loss) income to net cash provided by operating activities: |  |
Change in estimated fair value of contingent liabilities | (1,378) | (39,377)
Depreciation and amortization of intangible assets | 40,399 | 37,902
Amortization of premium on investments, net | 75 | 145
Amortization of debt discount and issuance fees | 639 | 12,863
Amortization of commercial license rights | (163) | 96
Loss (gain) on debt extinguishment | (4,192) | 7,303
Share-based compensation | 31,140 | 28,375
Deferred income taxes | (25,570) | (8,229)
Loss (gain) from short-term investments | 15,709 | (8,135)
Lease amortization expense | 4,535 | 3,349
Other | (45) | 658
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 20,550 | (8,838)
Inventory | 10,702 | (3,103)
Accounts payable and accrued liabilities | (405) | (3,635)
Income tax receivable and payable | 15,111 | (4,167)
Deferred revenue | (5,182) | (20,696)
Other assets and liabilities | (1,671) | (5,909)
Net cash provided by operating activities | 84,378 | 51,156
Cash flows from investing activities: |  |
Purchase of short-term investments | (39,052) | (116,898)
Proceeds from sale of short-term investments | 202,552 | 152,465
Proceeds from maturity of short-term investments | 24,830 | 37,100
Cash paid for equity method investment | (750) | 0
Purchase of property and equipment | (15,792) | (6,566)
Payments to CVR Holders | (960) | 0
Other | 80 | 135
Net cash provided by investing activities | 170,908 | 66,236
Cash flows from financing activities: |  |
Repurchase of 2023 Notes | (260,949) | (155,760)
Payments under financing lease obligations | (42) | (9,188)
Proceeds from convertible bond hedge settlement | 202 | 18,938
Payments to convertible bond holders for warrant purchases | 0 | (18,446)
Net proceeds from stock option exercises and ESPP | 1,831 | 29,484
Taxes paid related to net share settlement of equity awards | (6,018) | (5,903)
Payments to CVR Holders | (1,545) | (1,050)
Payments for OmniAb transaction costs | (4,171) | 0
Net cash used in financing activities | (270,692) | (141,925)
Net decrease in cash, cash equivalents and restricted cash | (15,406) | (24,533)
Cash, cash equivalents and restricted cash at beginning of period | 19,522 | 47,963
Cash, cash equivalents and restricted cash at end of period | 4,116 | 23,430
Supplemental disclosure of cash flow information: |  |
Interest paid | 1,139 | 1,740
Taxes paid | 6,630 | 3,720
Supplemental schedule of non-cash activity: |  |
Accrued fixed asset purchases | 3,626 | 557
Accrued inventory purchases | 7,676 | 4,968
Unrealized loss on AFS investments | $ (143) | $ (74)

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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition The cash inflow from a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 27 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3581-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash inflow from maturities, prepayments, calls and collections of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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