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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | $ 12,597 | $ 9,754 | $ 31,140 | $ 28,375
SBC - Research and development expenses |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | 6,104 | 4,480 | 14,519 | 12,975
SBC - General and administrative expenses |  |  |  |
Basis of Presentation [Line Items] |  |  |  |
Share-based compensation expense | $ 6,493 | $ 5,274 | $ 16,621 | $ 15,400

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