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Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 31, 2017 USD ($) | May 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2022 USD ($) | Sep. 30, 2022 USD ($) | Jun. 30, 2022 USD ($) | Mar. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Sep. 30, 2021 USD ($) | Jun. 30, 2021 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2022 USD ($) segment | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2007 $ / shares | Oct. 31, 2020 USD ($) $ / shares | Oct. 01, 2020 USD ($) | Jan. 01, 2020 USD ($) | Dec. 31, 2019 USD ($) | Jan. 31, 2010 right
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of business segments | segment |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |
Maturity period of cash and cash equivalents, maximum |  |  |  |  |  |  |  |  |  |  |  | 3 months |  |  |  |  |  |  |  |
Write-downs related to obsolete inventory |  |  |  |  |  |  |  |  |  |  |  | $ 1,100,000 | $ 0 | $ 0 |  |  |  |  |  |
Inventory |  |  |  | $ 13,294,000 |  |  |  | $ 27,326,000 |  |  |  | 13,294,000 | 27,326,000 |  |  |  |  |  |  |
Total revenues |  |  |  | 50,382,000 | $ 59,221,000 | $ 50,126,000 | $ 36,516,000 | 56,404,000 | $ 59,694,000 | $ 78,854,000 | $ 46,592,000 | 196,245,000 | 241,544,000 | 163,562,000 |  |  |  |  |  |
Credit loss adjustments on finite-lived intangible assets |  |  |  | (6,500,000) |  |  |  | (6,500,000) |  |  |  | (6,500,000) | (6,500,000) |  |  |  |  |  |  |
Additional reserve for credit losses due to COVID-19 |  |  |  |  |  |  |  |  |  |  |  | 300,000 | 500,000 |  |  |  |  |  |  |
Revenue recognized |  |  |  |  |  |  |  |  |  |  |  | 400,000 | 23,300,000 |  |  |  |  |  |  |
Dividend declared (USD per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.50 |  |  |  |  |
Decrease of deferred tax liabilities |  |  |  | (30,615,000) |  |  |  | (30,856,000) |  |  |  | (30,615,000) | (30,856,000) |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  | (597,485,000) |  |  |  | (821,159,000) |  |  |  | (597,485,000) | (821,159,000) | (709,525,000) |  |  |  |  | $ (767,232,000) |
Additional paid-in capital |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  | (147,590,000) |  |  |  | (372,969,000) |  |  |  | (147,590,000) | (372,969,000) | (318,358,000) |  |  |  |  | (367,326,000) |
Retain earnings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  | (450,862,000) |  |  |  | (449,090,000) |  |  |  | (450,862,000) | (449,090,000) | (391,952,000) |  |  |  |  | (400,105,000) |
Cumulative Effect, Period of Adoption, Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  |  |  |  |  | 15,997,000 |  |  |  |  | 15,997,000 |  |  |  |  |  | 5,168,000 |
Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  |  |  |  |  | 51,130,000 |  |  |  |  | 51,130,000 |  |  |  |  |  |  |
Cumulative Effect, Period of Adoption, Adjustment | Retain earnings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  |  |  |  |  | (35,133,000) |  |  |  |  | (35,133,000) |  |  |  |  |  | $ 5,168,000 |
Cumulative Effect, Period of Adoption, Adjusted Balance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in carrying amount of notes |  |  |  |  |  |  |  | (341,100,000) |  |  |  |  | (341,100,000) |  |  |  |  |  |  |
Unamortized discount |  |  |  |  |  |  |  | 2,200,000 |  |  |  |  | 2,200,000 |  |  |  |  |  |  |
Accounting Standards Update 2020-06 | Cumulative Effect, Period of Adoption, Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in carrying amount of notes |  |  |  |  |  |  |  | (20,400,000) |  |  |  |  | (20,400,000) |  |  |  |  |  |  |
Decrease of deferred tax liabilities |  |  |  |  |  |  |  | 4,400,000 |  |  |  |  | 4,400,000 |  |  |  |  |  |  |
Accounting Standards Update 2020-06 | Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  |  |  |  |  | 51,100,000 |  |  |  |  | 51,100,000 |  |  |  |  |  |  |
Accounting Standards Update 2020-06 | Cumulative Effect, Period of Adoption, Adjustment | Retain earnings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease (increase) in stockholder's equity |  |  |  |  |  |  |  | (35,100,000) |  |  |  |  | (35,100,000) |  |  |  |  |  |  |
Contract revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  |  |  |  | 19,223,000 | 28,367,000 | 19,807,000 |  |  |  |  |  |
Captisol |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Inventory |  |  |  | 5,900,000 |  |  |  | 24,600,000 |  |  |  | 5,900,000 | 24,600,000 |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  |  |  |  | $ 104,495,000 | 164,250,000 | 109,959,000 |  |  |  |  |  |
Stock options | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award expiration period |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |
Stock options | Vest 1/8 on the six month anniversary of the date of grant | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  |  |  |  | 6 months |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 12.50% |  |  |  |  |  |  |  |
Stock options | Vest 1/48 each month for forty-two months | 2002 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  |  |  |  | 42 months |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 2.08% |  |  |  |  |  |  |  |
RSUs and PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |
PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting period |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |
Minimum | PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 0.00% |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, useful life |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |
Maximum | PSUs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Award vesting right (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 200.00% |  |  |  |  |  |  |  |
Pfenex |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration liability per share (USD per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.00 |  |  |  |
Contingent consideration liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 77,800,000 | $ 77,800,000 |  |  |
Metabasis Therapeutics |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of contingent value rights | right |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4
Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 20.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets, net |  |  |  | $ 10,182,000 |  |  |  | $ 10,110,000 |  |  |  | $ 10,182,000 | $ 10,110,000 |  |  |  |  |  |  |
Licensing Agreements | Accounting Standards Update 2016-13 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Credit loss adjustments on finite-lived intangible assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (5,500,000) |  |
Novan | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones |  | $ 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Royalty Agreements | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  | 10.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novan | Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment for license |  | $ 12,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Contract revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,000,000 |  |  |  |  |  |
Palvella | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones |  |  | $ 8,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) |  |  | 9.80% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Palvella | Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment for license |  |  | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets, net |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |
Aziyo | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from royalties received | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate of forecasted cash flows (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 19.00% |  |  |  |  |  |  |  |
Aziyo | Royalty Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional royalties receivable under sales-based milestones | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
CorMatrix | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Product royalty (as a percent) | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period of royalty agreement | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Selexis | Royalty Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate of forecasted cash flows (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 24.60% |  |  |  |  |  |  |  |
Dividend yield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis of Presentation [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Measurement input (as a percent) |  |  |  | 0 |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |

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