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Balance Sheet Account Details - Contingent Liabilities (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Contingent Liability [Roll Forward] |  |
Commercial rights, beginning of period | $ 3,707 | $ 41,929
Payments | 0 | (50)
Fair Value Adjustment | (194) | (38,172)
Repurchases | 0 |
Commercial rights, end of period | 3,513 | 3,707
Cydex |  |
Contingent Liability [Roll Forward] |  |
Commercial rights, beginning of period | 349 | 507
Payments | 0 | (50)
Fair Value Adjustment | (265) | (108)
Repurchases | 0 |
Commercial rights, end of period | 84 | 349
Metabasis |  |
Contingent Liability [Roll Forward] |  |
Commercial rights, beginning of period | 3,358 | 3,822
Payments | 0 | 0
Fair Value Adjustment | 71 | (464)
Repurchases | 0 |
Commercial rights, end of period | 3,429 | 3,358
Pfenex |  |
Contingent Liability [Roll Forward] |  |
Commercial rights, beginning of period | 0 | 37,600
Payments | 0 | 0
Fair Value Adjustment | 0 | (37,600)
Repurchases | 0 |
Commercial rights, end of period | $ 0 | $ 0

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- Definition Business Acquisition Contingent Consideration Potential Cash Payment at End of Period + References No definition available. + Details
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Namespace Prefix: | lgnd_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition Contingent Liability [Roll Forward] + References No definition available. + Details
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Balance Type: | na
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- Definition Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Repurchases, Contingent Liabilities + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
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Period Type: | duration

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- Definition Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
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- Definition Payments to contingent value right holders + References No definition available. + Details
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Namespace Prefix: | lgnd_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Details
Name: | us-gaap_BusinessAcquisitionAxis=lgnd_CydexPharmaceuticalsIncMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember
Namespace Prefix: |
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Balance Type: |
Period Type: |

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- Details
Name: | us-gaap_BusinessAcquisitionAxis=lgnd_PfenexMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |